Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3321373 | 1.00 | MAP2K1 (0.43) | MAP2K1SLC6A4HTR6SLC6A2SLC6A3 | |
| SCHEMBL3325058 | 0.87 | SLC6A2 (0.45) | MAP2K1SLC6A4SLC6A2SLC6A3CYP2D6 | |
| SCHEMBL3329880 | 0.87 | SLC6A2 (0.45) | MAP2K1SLC6A4SLC6A2SLC6A3CYP2D6 | |
| SCHEMBL3325733 | 0.86 | SLC6A2 (0.51) | MAP2K1SLC6A4SLC6A2SLC6A3CYP2D6 | |
| SCHEMBL3325140 | 0.86 | MAP2K1 (0.41) | MAP2K1SLC6A4SLC6A2SLC6A3CYP2D6 | |
| SCHEMBL3329940 | 0.86 | SLC6A2 (0.51) | MAP2K1SLC6A4SLC6A2SLC6A3CYP2D6 | |
| SCHEMBL3325149 | 0.86 | MAP2K1 (0.41) | MAP2K1SLC6A4SLC6A2SLC6A3CYP2D6 | |
| SCHEMBL3324991 | 0.85 | SLC6A4 (0.48) | SLC6A4HTR6SLC6A2SLC6A3CYP2D6 | |
| SCHEMBL3324998 | 0.85 | SLC6A4 (0.48) | SLC6A4HTR6SLC6A2SLC6A3CYP2D6 | |
| SCHEMBL3324811 | 0.83 | IKBKB (0.50) | MAP2K1SLC6A4SLC6A2SLC6A3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100120858-A1 | Piperidine Derivatives | PFIZER INC. | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120858-A1 | Piperidine Derivatives | P2RX5, P2RX7, P2RX1 | MAP2K1 4782/4885SLC6A4 1898/4885HTR6 832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.