Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 3/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | WNT1 | P04628 | 5/20 | 0.36 |
| ▸ | GSK3B | P49841 | 5/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 2/20 | 0.34 |
| ▸ | CLK1 | P49759 | 3/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | CLK3 | P49761 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3321393 | 1.00 | FGFR1 (0.39) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL1571575 | 0.84 | GSK3B (0.47) | WNT1GSK3BDYRK1ARETPRMT5 | |
| SCHEMBL3323284 | 0.84 | GSK3B (0.47) | WNT1GSK3BDYRK1ARETPRMT5 | |
| SCHEMBL3321397 | 0.81 | FGFR1 (0.41) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL3323415 | 0.80 | CLK1 (0.35) | GSK3BDYRK1AACACBMAP4K1RET | |
| SCHEMBL3323419 | 0.80 | CLK1 (0.35) | GSK3BDYRK1AACACBMAP4K1RET | |
| SCHEMBL3502615 | 0.79 | HCAR2 (0.38) | GSK3BDYRK1AACACBCLK1PRMT5 | |
| SCHEMBL1869804 | 0.78 | GSK3B (0.48) | WNT1GSK3BDYRK1ARETCLK1 | |
| SCHEMBL1869803 | 0.78 | GSK3B (0.48) | WNT1GSK3BDYRK1ARETCLK1 | |
| SCHEMBL3317175 | 0.78 | GSK3B (0.48) | WNT1GSK3BDYRK1ARETCLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216767-A1 | QUINAZOLINES FOR PDK1 INHIBITION | AIKAWA MINA | 2010-08-26 | — | — | US | disclosed |
| US-20100121052-A1 | Novel compounds for treating proliferative diseases | JAIN RAMA | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216767-A1 | QUINAZOLINES FOR PDK1 INHIBITION | PDK1, PDK2, PDK3 | FGFR1 794/4885FGFR2 2150/4885FGFR4 2147/4885 |
| US-20100121052-A1 | Novel compounds for treating proliferative diseases | PDK1, PDK2, PDK3 | FGFR1 236/4885FGFR2 805/4885FGFR4 1024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.