Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 20/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3322111 | 1.00 | TRPV1 (0.54) | TRPV1CYP2D6CYP3A4 | |
| SCHEMBL3327841 | 0.93 | TRPV1 (0.62) | TRPV1CYP2D6CYP3A4 | |
| SCHEMBL3321618 | 0.89 | TRPV1 (0.53) | TRPV1CYP2D6CYP3A4 | |
| SCHEMBL3323454 | 0.89 | TRPV1 (0.47) | TRPV1CYP2D6CYP3A4 | |
| SCHEMBL3320731 | 0.89 | TRPV1 (0.53) | TRPV1CYP2D6CYP3A4 | |
| SCHEMBL3320905 | 0.89 | TRPV1 (0.53) | TRPV1CYP2D6CYP3A4 | |
| SCHEMBL3322715 | 0.85 | TRPV1 (0.52) | TRPV1CYP2D6CYP3A4 | |
| SCHEMBL3322541 | 0.84 | TRPV1 (0.51) | TRPV1CYP2D6CYP3A4 | |
| SCHEMBL3329101 | 0.80 | TRPV1 (0.61) | TRPV1CYP2D6CYP3A4 | |
| SCHEMBL3332747 | 0.78 | TRPV1 (0.51) | TRPV1CYP2D6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8609692-B2 | TRPV1 antagonists | ABBVIE INC. (US) | 2013-12-17 | — | — | US | disclosed |
| US-20100120846-A1 | TRPV1 ANTAGONISTS | ABBOTT LABORATORIES (US) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120846-A1 | TRPV1 ANTAGONISTS | TRPV1, TRPV3, TRPV2 | TRPV1 1/4885CYP2D6 875/4885CYP3A4 1264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.