Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20764789 | 0.72 | — | — | |
| SCHEMBL7376358 | 0.70 | ALDH1A1 (0.33) | ALDH1A1HRH4HRH3 | |
| SCHEMBL27784570 | 0.70 | PHGDH (0.37) | ALDH1A1HRH3 | |
| SCHEMBL14395629 | 0.69 | ALDH1A1 (0.32) | ALDH1A1HRH4HRH3 | |
| SCHEMBL6631181 | 0.69 | ALDH1A1 (0.35) | ALDH1A1HRH4HRH3 | |
| SCHEMBL20684117 | 0.69 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL1448833 | 0.66 | — | — | |
| SCHEMBL16841255 | 0.65 | HRH3 (0.45) | ALDH1A1HRH4HRH3 | |
| SCHEMBL3538083 | 0.65 | HRH3 (0.45) | ALDH1A1HRH4HRH3 | |
| SCHEMBL12124997 | 0.65 | HRH3 (0.45) | ALDH1A1HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288432-B2 | Tetrahydroindole derivatives as NADPH oxidase inhibitors | GENKYOTEX SA (CH) | 2012-10-16 | — | — | US | disclosed |
| US-20100120749-A1 | TETRAHYDROINDOLE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYO TEX SA (CH) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120749-A1 | TETRAHYDROINDOLE DERIVATIVES AS NADPH OXIDASE INHIBITORS | CYBB, NQO1, NOX4 | ALDH1A1 199/4885HRH4 502/4885HRH3 742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.