Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 12/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3323862 | 1.00 | TRPV1 (0.41) | TRPV1HTR2AHTR2CHTR2BCYP2D6 | |
| SCHEMBL3324584 | 0.87 | TRPV1 (0.35) | TRPV1HTR2AHTR2CHTR2B | |
| SCHEMBL3324588 | 0.87 | TRPV1 (0.35) | TRPV1HTR2AHTR2CHTR2B | |
| SCHEMBL3323873 | 0.82 | TRPV1 (0.44) | TRPV1CYP2D6 | |
| SCHEMBL3323877 | 0.82 | TRPV1 (0.44) | TRPV1CYP2D6 | |
| SCHEMBL2317663 | 0.79 | TRPV1 (0.41) | TRPV1HTR2CHTR2BCYP2D6 | |
| SCHEMBL2317667 | 0.79 | TRPV1 (0.41) | TRPV1HTR2CHTR2BCYP2D6 | |
| SCHEMBL3319767 | 0.78 | TRPV1 (0.39) | TRPV1HTR2AHTR2CHTR2B | |
| SCHEMBL3319774 | 0.78 | TRPV1 (0.39) | TRPV1HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL6559911 | 0.77 | TRPV1 (0.38) | TRPV1HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796328-B2 | TRPV1 antagonists | ABBVIE INC. | 2014-08-05 | — | — | US | disclosed |
| US-20130345255-A1 | TRPV1 ANTAGONISTS | ABBVIE INC. | 2013-12-26 | — | — | US | disclosed |
| US-8609692-B2 | TRPV1 antagonists | ABBVIE INC. (US) | 2013-12-17 | — | — | US | disclosed |
| US-8604053-B2 | TRPV1 antagonists | ABBVIE INC. (US) | 2013-12-10 | — | — | US | disclosed |
| US-20100137360-A1 | TRPV1 ANTAGONISTS | ABBOTT LABORATORIES (US) | 2010-06-03 | — | — | US | disclosed |
| US-20100120846-A1 | TRPV1 ANTAGONISTS | ABBOTT LABORATORIES (US) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137360-A1 | TRPV1 ANTAGONISTS | TRPV1, TRPV3, TRPV2 | TRPV1 1/4885HTR2A 195/4885HTR2C 216/4885 |
| US-20100120846-A1 | TRPV1 ANTAGONISTS | TRPV1, TRPV3, TRPV2 | TRPV1 1/4885HTR2A 201/4885HTR2C 224/4885 |
| US-20130345255-A1 | TRPV1 ANTAGONISTS | TRPV1, NPY1R, OPRL1 | TRPV1 1/4885HTR2A 217/4885HTR2C 362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.