Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.43 |
| ▸ | CHUK | O15111 | 2/20 | 0.43 |
| ▸ | PIM1 | P11309 | 2/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | NPY1R | P25929 | 2/20 | 0.37 |
| ▸ | EED | O75530 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3323985 | 1.00 | IKBKB (0.43) | IKBKBCHUKPIM1PIM2IRAK4 | |
| SCHEMBL3324556 | 0.90 | IKBKB (0.46) | IKBKBCHUKPIM1PIM2IRAK4 | |
| SCHEMBL3324549 | 0.90 | IKBKB (0.46) | IKBKBCHUKPIM1PIM2IRAK4 | |
| SCHEMBL3321059 | 0.89 | IKBKB (0.42) | IKBKBCHUKPIM1PIM2IRAK4 | |
| SCHEMBL3321055 | 0.89 | IKBKB (0.42) | IKBKBCHUKPIM1PIM2IRAK4 | |
| SCHEMBL3326810 | 0.89 | IKBKB (0.42) | IKBKBCHUKPIM1PIM2IRAK4 | |
| SCHEMBL3325475 | 0.89 | IKBKB (0.42) | IKBKBCHUKPIM1PIM2IRAK4 | |
| SCHEMBL3322084 | 0.86 | PIM1 (0.43) | IKBKBCHUKPIM1PIM2IRAK4 | |
| SCHEMBL3322089 | 0.86 | PIM1 (0.43) | IKBKBCHUKPIM1PIM2IRAK4 | |
| SCHEMBL3321236 | 0.85 | IKBKB (0.51) | IKBKBCHUKPIM1PIM2IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100120858-A1 | Piperidine Derivatives | PFIZER INC. | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120858-A1 | Piperidine Derivatives | P2RX5, P2RX7, P2RX1 | IKBKB 1359/4885CHUK 2338/4885PIM1 3450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.