Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3324546 | 1.00 | CRHR1 (0.45) | CRHR1ALDH1A1KDM4EAPPMEN1 | |
| SCHEMBL3324545 | 1.00 | CRHR1 (0.45) | CRHR1ALDH1A1KDM4EAPPMEN1 | |
| SCHEMBL438297 | 0.84 | MAPT (0.48) | ALDH1A1KDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL438854 | 0.82 | ALDH1A1 (0.47) | CRHR1ALDH1A1KDM4EAPPMEN1 | |
| SCHEMBL438852 | 0.82 | ALDH1A1 (0.47) | CRHR1ALDH1A1KDM4EAPPMEN1 | |
| SCHEMBL438853 | 0.82 | ALDH1A1 (0.47) | CRHR1ALDH1A1KDM4EAPPMEN1 | |
| SCHEMBL438412 | 0.81 | ALDH1A1 (0.46) | CRHR1ALDH1A1KDM4EAPPMEN1 | |
| SCHEMBL438411 | 0.81 | ALDH1A1 (0.46) | CRHR1ALDH1A1KDM4EAPPMEN1 | |
| SCHEMBL438413 | 0.81 | ALDH1A1 (0.46) | CRHR1ALDH1A1KDM4EAPPMEN1 | |
| SCHEMBL442308 | 0.80 | MAPT (0.47) | CRHR1ALDH1A1MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100120741-A1 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120741-A1 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | HRH4, HRH3, HRH2 | CRHR1 167/4885ALDH1A1 1909/4885KDM4E 1897/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.