Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.42 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.42 |
| ▸ | CCNK | O75909 | 9/20 | 0.42 |
| ▸ | CDK12 | Q9NYV4 | 9/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL183265 | 0.73 | KCNN3 (0.76) | KCNN2KCNN3CCNKCDK12NPSR1 | |
| SCHEMBL183708 | 0.72 | KCNN2 (0.70) | KCNN2KCNN3NPSR1HTTSMN1; SMN2 | |
| SCHEMBL240874 | 0.72 | KCNN3 (0.61) | KCNN2KCNN3CCNKCDK12TP53 | |
| SCHEMBL3591520 | 0.71 | KCNN3 (0.58) | KCNN2KCNN3NPSR1HTTSMN1; SMN2 | |
| SCHEMBL183217 | 0.71 | NPSR1 (0.57) | KCNN2KCNN3CCNKCDK12NPSR1 | |
| SCHEMBL183371 | 0.69 | KCNN3 (0.57) | KCNN2KCNN3NPSR1HTTSMN1; SMN2 | |
| SCHEMBL183218 | 0.69 | CCNK (0.37) | KCNN2KCNN3CCNKCDK12NPSR1 | |
| SCHEMBL182996 | 0.68 | KCNN3 (0.80) | KCNN2KCNN3NPSR1HTTSMN1; SMN2 | |
| SCHEMBL183101 | 0.67 | KCNN2 (0.59) | KCNN2KCNN3NPSR1HTTSMN1; SMN2 | |
| SCHEMBL183318 | 0.64 | KCNN3 (0.71) | KCNN2KCNN3NPSR1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8362024-B2 | Purinyl derivatives and their use as potassium channel modulators | NEUROSEARCH A/S (DK) | 2013-01-29 | — | — | US | disclosed |
| US-20100120797-A1 | PURINYL DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120797-A1 | PURINYL DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | KCNJ2, KCNJ5, KCNJ3 | KCNN2 5/4885KCNN3 15/4885CCNK 3547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.