Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 12/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 12/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 12/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 12/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 12/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 12/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17555891 | 0.81 | PDE3B (0.49) | PDE3BPDE3ACYP2E1CYP2A6PSEN1 | |
| SCHEMBL13361895 | 0.78 | PDE3B (0.45) | PDE3BPDE3ACYP2E1CYP2A6PSEN1 | |
| SCHEMBL3317315 | 0.77 | PDE3B (0.47) | PDE3BPDE3ACYP2E1CYP2A6PSEN1 | |
| SCHEMBL3754489 | 0.73 | PSEN1 (0.42) | CYP2E1CYP2A6PSEN1PSEN2APH1B | |
| SCHEMBL3947341 | 0.70 | ALDH1A1 (0.45) | — | |
| SCHEMBL511511 | 0.70 | NR4A1 (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL15222204 | 0.70 | MAOA (0.50) | CYP2E1CYP2A6PSEN1PSEN2APH1B | |
| SCHEMBL4119372 | 0.70 | CYP1A2 (0.36) | PDE3BPDE3ACYP2E1CYP2A6PSEN1 | |
| SCHEMBL14353296 | 0.69 | IKBKB (0.41) | MAOACYP3A4 | |
| SCHEMBL6127790 | 0.69 | PSEN1 (0.43) | CYP2E1CYP2A6PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010054253-A1 | TRIAZINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASES | BIOTIE THERAPIES GMBH (DE) | 2010-05-14 | — | — | WO | disclosed |
| US-20100120762-A1 | Triazine derivatives as inhibitors of phosphodiesterases | WYETH (US) | 2010-05-13 | — | — | US | disclosed |
| US-20100120762-A1 | Triazine derivatives as inhibitors of phosphodiesterases | WYETH (US) | 2010-05-13 | — | — | US | disclosed |
| US-20100120762-A1 | Triazine derivatives as inhibitors of phosphodiesterases | WYETH (US) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120762-A1 | Triazine derivatives as inhibitors of phosphodiesterases | PDE2A, PDE5A, PDE12 | PDE3B 7/4885PDE3A 4/4885CYP2E1 754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.