Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 12/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 12/20 | 0.49 |
| ▸ | PDE6D | O43924 | 3/20 | 0.49 |
| ▸ | PDE6A | P16499 | 3/20 | 0.49 |
| ▸ | PDE6G | P18545 | 3/20 | 0.49 |
| ▸ | PDE6B | P35913 | 3/20 | 0.49 |
| ▸ | PDE6C | P51160 | 3/20 | 0.49 |
| ▸ | PDE6H | Q13956 | 3/20 | 0.49 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.48 |
| ▸ | PDE5A | O76074 | 2/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3324079 | 0.88 | PDE2A (0.39) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL12947963 | 0.84 | PDE2A (0.46) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL969708 | 0.82 | PDE2A (0.45) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL3326278 | 0.77 | PDE2A (0.52) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL13361919 | 0.77 | CYP11B1 (0.40) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL3325055 | 0.71 | PDE10A (0.43) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL3327099 | 0.70 | PTGS2 (0.37) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL8031003 | 0.69 | ATP4A (0.41) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL7914351 | 0.69 | PTGS2 (0.37) | PDE2APDE10ACYP11B1CYP11B2CYP1A2 | |
| SCHEMBL3325445 | 0.66 | PDE2A (1.00) | PDE2APDE10APDE6DPDE6APDE6G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010054260-A1 | IMIDAZO[5,1-C][1,2,4]BENZOTRIAZINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASES | BIOTIE THERAPIES GMBH (DE) | 2010-05-14 | — | — | WO | disclosed |
| US-20100120763-A1 | IMIDAZO[5,1-C][1,2,4]BENZOTRIAZINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASES | WYETH (US) | 2010-05-13 | — | — | US | disclosed |
| US-20100120763-A1 | IMIDAZO[5,1-C][1,2,4]BENZOTRIAZINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASES | WYETH (US) | 2010-05-13 | — | — | US | disclosed |
| US-20100120763-A1 | IMIDAZO[5,1-C][1,2,4]BENZOTRIAZINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASES | WYETH (US) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120763-A1 | IMIDAZO[5,1-C][1,2,4]BENZOTRIAZINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASES | PDE2A, PDE5A, PDE3A | PDE2A 1/4885PDE10A 13/4885PDE6D 121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.