Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 3/20 | 0.66 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.59 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.58 |
| ▸ | CACNA1F | O60840 | 4/20 | 0.57 |
| ▸ | CACNA1D | Q01668 | 4/20 | 0.57 |
| ▸ | CACNA1S | Q13698 | 4/20 | 0.57 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29676320 | 1.00 | TSHR (0.69) | TSHRNPSR1POLBADORA3CACNA1B | |
| SCHEMBL28735878 | 0.89 | TSHR (0.59) | TSHRNPSR1POLBADORA3CACNA1B | |
| SCHEMBL3032551 | 0.86 | CACNA1F (0.66) | TSHRPOLBADORA3CACNA1BCACNA1F | |
| SCHEMBL3024959 | 0.85 | CACNA1B (0.62) | TSHRNPSR1POLBADORA3CACNA1B | |
| SCHEMBL7434340 | 0.85 | ADORA3 (0.62) | TSHRPOLBADORA3CACNA1BCACNA1F | |
| SCHEMBL3034907 | 0.85 | NR3C2 (0.61) | TSHRNPSR1POLBADORA3CACNA1B | |
| SCHEMBL11783074 | 0.84 | GAA (0.64) | TSHRPOLBADORA3CACNA1FCACNA1D | |
| SCHEMBL10540800 | 0.84 | ADORA3 (0.60) | TSHRNPSR1POLBADORA3CACNA1F | |
| SCHEMBL7345493 | 0.84 | POLB (0.54) | TSHRNPSR1POLBADORA3CACNA1B | |
| SCHEMBL7345498 | 0.84 | ADORA3 (0.64) | TSHRNPSR1POLBADORA3CACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | ARCHER PHARMACEUTICALS, INC. (US) | 2010-05-13 | — | — | US | disclosed |
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | ARCHER PHARMACEUTICALS, INC. (US) | 2010-05-13 | — | — | US | disclosed |
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | ARCHER PHARMACEUTICALS, INC. (US) | 2010-05-13 | — | — | US | disclosed |
| US-4567268-A | Process for preparation of certain tetrahydrofuro[3,4-b]pyridines | MERCK & CO., INC. (US) | 1986-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | APP, MAPT, PSEN1 | TSHR 4847/4885NPSR1 3203/4885POLB 606/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.