Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.46 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28044388 | 0.91 | CA1 (0.36) | CA4FAHD1CA1CA2 | |
| Bicarbonate SCHEMBL11228006 | 0.91 | — | — | |
| Bicarbonate SCHEMBL3824855 | 0.87 | CA4 (0.43) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL3802190 | 0.87 | CA1 (0.33) | CA4FAHD1CA1 | |
| Bicarbonate SCHEMBL10774604 | 0.84 | CA4 (0.50) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL11203856 | 0.82 | CA1 (0.55) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL5912779 | 0.82 | CA1 (0.46) | CA4FAHD1CA1CA2 | |
| Bicarbonate SCHEMBL8594161 | 0.82 | CA1 (0.55) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL29273171 | 0.81 | CA1 (0.43) | CA4FAHD1CA1MEN1LDHA | |
| Sulfurous Acid SCHEMBL11718648 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100129436-A1 | SUBTANCES FOR THE PROTECTION OF CELLS AND/OR TISSUES | LOSEL RALF | 2010-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100129436-A1 | SUBTANCES FOR THE PROTECTION OF CELLS AND/OR TISSUES | CTSA, BCL2, BAX | CA4 2706/4885FAHD1 2042/4885CA1 1014/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.