Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 12/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.48 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.47 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.47 |
| ▸ | CCR5 | P51681 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3327462 | 1.00 | EPHX2 (0.57) | EPHX2HRH3TRPV4TEAD1CCR5 | |
| SCHEMBL5438452 | 1.00 | EPHX2 (0.57) | EPHX2HRH3TRPV4TEAD1CCR5 | |
| SCHEMBL3325380 | 0.91 | HRH3 (0.58) | EPHX2HRH3TRPV4 | |
| SCHEMBL3325382 | 0.91 | HRH3 (0.58) | EPHX2HRH3TRPV4 | |
| SCHEMBL3326510 | 0.87 | HRH3 (0.54) | HRH3 | |
| SCHEMBL3327503 | 0.87 | HRH3 (0.54) | HRH3 | |
| SCHEMBL3326514 | 0.87 | HRH3 (0.54) | HRH3 | |
| SCHEMBL27752283 | 0.86 | ALDH1A1 (0.49) | EPHX2HRH3TRPV4 | |
| SCHEMBL3325486 | 0.85 | L3MBTL1 (0.48) | HRH3 | |
| SCHEMBL3324081 | 0.85 | EPHX2 (0.59) | EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100120769-A1 | CYCLOHEXYL PIPERAZINYL METHANONE DERIVATIVES | NETTEKOVEN MATTHIAS | 2010-05-13 | — | — | US | disclosed |
| US-20070167436-A1 | Cyclohexyl piperazinyl methanone derivatives | HOFFMANN-LA ROCHE INC. | 2007-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120769-A1 | CYCLOHEXYL PIPERAZINYL METHANONE DERIVATIVES | HRH3, HRH4, HRH1 | EPHX2 3709/4885HRH3 1/4885TRPV4 658/4885 |
| US-20070167436-A1 | Cyclohexyl piperazinyl methanone derivatives | HRH3, HRH4, HRH1 | EPHX2 3709/4885HRH3 1/4885TRPV4 658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.