Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 20/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3327813 | 1.00 | KCNH2 (0.45) | KCNH2 | |
| SCHEMBL3326917 | 0.90 | KCNH2 (0.56) | KCNH2 | |
| SCHEMBL3331892 | 0.90 | KCNH2 (0.37) | KCNH2 | |
| SCHEMBL3331050 | 0.88 | KCNH2 (0.35) | KCNH2 | |
| SCHEMBL3220103 | 0.86 | HSD11B1 (0.34) | KCNH2 | |
| SCHEMBL3325759 | 0.86 | KCNH2 (0.34) | KCNH2 | |
| SCHEMBL2766739 | 0.82 | KCNH2 (0.49) | KCNH2 | |
| SCHEMBL2770444 | 0.82 | KCNH2 (0.49) | KCNH2 | |
| SCHEMBL2768674 | 0.81 | KCNH2 (0.51) | KCNH2 | |
| SCHEMBL14461107 | 0.78 | KCNH2 (0.49) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137353-A1 | TRICYCLIC COMPOUNDS AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137353-A1 | TRICYCLIC COMPOUNDS AS ANTIBACTERIALS | NRDC, NACA, NOP2 | KCNH2 2974/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.