Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | WDR5 | P61964 | 4/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | PRKACG | P22612 | 1/20 | 0.35 |
| ▸ | PRKACB | P22694 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.34 |
| ▸ | CHRNG | P07510 | 1/20 | 0.34 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19330905 | 0.91 | KMT2A (0.36) | KMT2APIK3CDWDR5OPRM1PRKACA | |
| SCHEMBL3206919 | 0.88 | KMT2A (0.45) | KMT2AWDR5OPRM1OPRL1 | |
| SCHEMBL1492681 | 0.85 | WDR5 (0.46) | KMT2AWDR5OPRM1 | |
| SCHEMBL17632371 | 0.85 | WDR5 (0.46) | KMT2AWDR5OPRM1LMNA | |
| SCHEMBL3171333 | 0.83 | WDR5 (0.47) | KMT2AWDR5OPRM1 | |
| SCHEMBL1598590 | 0.82 | KMT2A (0.41) | KMT2APIK3CDOPRM1PRKACAPRKACG | |
| SCHEMBL1599547 | 0.81 | KMT2A (0.40) | KMT2APIK3CDOPRM1PRKACAPRKACG | |
| SCHEMBL13439854 | 0.81 | PIK3CD (0.45) | KMT2APIK3CDOPRM1PRKACAPRKACG | |
| SCHEMBL7811081 | 0.81 | KMT2A (0.40) | KMT2APIK3CDOPRM1PRKACAPRKACG | |
| SCHEMBL625294 | 0.81 | ICMT (0.44) | KMT2APIK3CDOPRM1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6346624-B1 | ENZYME INHIBITORS FORMED BY DEHYDROHALOGENATION | PFIZER INC | 2002-02-12 | — | — | US | claimed |
| US-6344563-B1 | SULFIDING, DEHYDROHALOGENATION, FORMATION OF BOND BETWEEN CARBON AND NITROGEN | NORRIS TIMOTHY (US) | 2002-02-05 | — | — | US | claimed |
| CN-1291609-A | Method of preparing 5-lipoxidase inhibitor possessing different heterocyclic ring system | PFIZER PROD INC (US) | 2001-04-18 | — | — | CN | claimed |
| EP-1081143-A1 | Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems | Pfizer Products Inc. (US) | 2001-03-07 | — | — | EP | claimed |
| EP-1081146-A1 | Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems | Pfizer Products Inc. (US) | 2001-03-07 | — | — | EP | claimed |
| EP-1081144-A2 | Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems | Pfizer Products Inc. (US) | 2001-03-07 | — | — | EP | claimed |
| CN-1286250-A | Method for preparing 5-lipooxygenase inhibitor having changeable heterocycle system | PFIZER PROD INC (US) | 2001-03-07 | — | — | CN | claimed |
| EP-3209664-B1 | BICYCLIC HETEROARYL AMINE COMPOUNDS AS PI3K INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2020-06-03 | — | — | EP | disclosed |
| EP-3209664-B1 | BICYCLIC HETEROARYL AMINE COMPOUNDS AS PI3K INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2020-06-03 | — | — | EP | disclosed |
| US-20170355707-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2017-12-14 | — | — | US | disclosed |
| US-20170355707-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2017-12-14 | — | — | US | disclosed |
| US-20170355707-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2017-12-14 | — | — | US | disclosed |
| EP-3209664-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS AS PI3K INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-08-30 | — | — | EP | disclosed |
| CN-1291609-A | Method of preparing 5-lipoxidase inhibitor possessing different heterocyclic ring system | PFIZER PROD INC (US) | 2001-04-18 | — | — | CN | disclosed |
| EP-1081143-A1 | Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems | Pfizer Products Inc. (US) | 2001-03-07 | — | — | EP | disclosed |
| EP-1081146-A1 | Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems | Pfizer Products Inc. (US) | 2001-03-07 | — | — | EP | disclosed |
| EP-1081144-A2 | Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems | Pfizer Products Inc. (US) | 2001-03-07 | — | — | EP | disclosed |
| CN-1286250-A | Method for preparing 5-lipooxygenase inhibitor having changeable heterocycle system | PFIZER PROD INC (US) | 2001-03-07 | — | — | CN | disclosed |
| US-6194585-B1 | REACTING 4-(3-(4-(2-(ALKYL OR ARYL-IMIDAZOL-1-YL)-PHENYL SULFANYL)-PHENYL)-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID AMIDE WITH METHANESULFONIC ACID TO FORM CORRESPONDING METHANESULFONIC ACID | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-1029865-A2 | Process and intermediates for preparing 5-lipoxygenase inhibitors | Pfizer Products Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355707-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS | PIK3R3, JAK2, JAK3 | KMT2A 2535/4885PIK3CD 14/4885WDR5 2710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.