Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ranitidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 known ✓ | P25021 | 1/20 | 0.96 |
| ▸ | ACHE | P22303 | 15/20 | 0.96 |
| ▸ | MEN1 | O00255 | 1/20 | 0.96 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.96 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.96 |
| ▸ | LMNA | P02545 | 1/20 | 0.96 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.96 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.96 |
| ▸ | TSHR | P16473 | 1/20 | 0.96 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.96 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.96 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.96 |
| ▸ | ATP4A | P20648 | 1/20 | 0.96 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.96 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.96 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.96 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.96 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.96 |
| ▸ | ATP4B | P51164 | 1/20 | 0.96 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.96 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ranitidine SCHEMBL2228182 | 0.98 | ACHE (0.96) | ACHEMEN1SLC22A1ABCB11LMNA | |
| Ranitidine SCHEMBL826 | 0.98 | ACHE (1.00) | ACHEMEN1SLC22A1ABCB11LMNA | |
| Ranitidine SCHEMBL824 | 0.98 | ACHE (1.00) | ACHEMEN1SLC22A1ABCB11LMNA | |
| Ranitidine SCHEMBL8594797 | 0.98 | ACHE (1.00) | ACHEMEN1SLC22A1ABCB11LMNA | |
| Ranitidine SCHEMBL825 | 0.98 | ACHE (1.00) | ACHEMEN1SLC22A1ABCB11LMNA | |
| Ranitidine SCHEMBL8796367 | 0.98 | ACHE (1.00) | ACHEMEN1SLC22A1ABCB11LMNA | |
| Ranitidine SCHEMBL8488428 | 0.97 | ACHE (0.98) | ACHEMEN1SLC22A1ABCB11LMNA | |
| Ranitidine SCHEMBL33299 | 0.97 | RAD52 (1.00) | ACHEMEN1SLC22A1ABCB11LMNA | |
| Ranitidine SCHEMBL21618415 | 0.97 | ACHE (0.98) | ACHEMEN1SLC22A1ABCB11LMNA | |
| Ranitidine SCHEMBL33298 | 0.97 | RAD52 (1.00) | ACHEMEN1SLC22A1ABCB11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 7990 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12601718-B2 | Method for pretreating ranitidine hydrochloride sample | Hunan Institute for Drug Inspection and Testing (CN) | 2026-04-14 | — | — | US | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| EP-4654949-A1 | USE OF VITAMIN E TPGS AS A TASTE MASKING AGENT FOR BITTER DRUGS | Hyloris Developments SA (BE) | 2025-12-03 | — | — | EP | claimed |
| US-20250242092-A1 | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS | SIO2 MEDICAL PRODUCTS INC (US) | 2025-07-31 | — | — | US | claimed |
| CN-119326718-B | Production process of ranitidine hydrochloride injection | 安徽长江药业有限公司 | 2025-04-22 | — | — | CN | claimed |
| CN-119751387-A | Synthesis method of ranitidine Ding Zazhi A hydrochloride | 江苏汉斯通药业有限公司 | 2025-04-04 | — | — | CN | claimed |
| US-12257371-B2 | SiOx barrier for pharmaceutical package and coating process | SIO2 MEDICAL PRODUCTS, LLC (US) | 2025-03-25 | — | — | US | claimed |
| CN-119569687-A | Preparation method of ranitidine hydrochloride small rod-shaped crystal habit | 江苏正济药业股份有限公司 | 2025-03-07 | — | — | CN | claimed |
| EP-4255414-B1 | COMPOSITION CONTAINING RANITIDINE HAVING A LOW IRON CONTENT | OPELLA HEALTHCARE GROUP SAS (FR) | 2025-02-05 | — | — | EP | claimed |
| CN-119326718-A | Production process of ranitidine hydrochloride injection | 安徽长江药业有限公司 | 2025-01-21 | — | — | CN | claimed |
| WO-1994020091-A1 | CRYSTALLINE CYCLODEXTRIN INCLUSION COMPLEXES OF RANITIDINE HYDROCHLORIDE AND PROCESS FOR THEIR PREPARATION | HEXAL PHARMA GMBH (DE) | 1994-09-15 | — | — | WO | claimed |
| US-5338871-A | Preparation of form 1 ranitidine hydrochloride | TORCAN CHEMICAL LTD. (CA) | 1994-08-16 | — | — | US | claimed |
| WO-1994008560-A1 | RANITIDINE CHEWABLE TABLETS | GLAXO GROUP LIMITED (GB) | 1994-04-28 | — | — | WO | claimed |
| WO-1994008576-A1 | TASTE-MASKING COMPOSITIONS OF RANITIDINE | GLAXO GROUP LIMITED (GB) | 1994-04-28 | — | — | WO | claimed |
| US-5219563-A | Contacting synthetic cation exchange resin with ranitidine or salt to form complex | GLAXO GROUP LIMITED (GB) | 1993-06-15 | — | — | US | claimed |
| US-5102665-A | Ranitidine or salts, monoalkali metal citrate, alkali or alkaline metal carbonates or bicarbonates for treatment of gastrointestinal disorder; antiinflammatory or/and antiallergic agent | GLAXO GROUP LIMITED (GB) | 1992-04-07 | — | — | US | claimed |
| US-5028432-A | Nonaqueous Matrix of Glyceride and/or Mineral Oil or Paraffin | GLAXO CANADA, INC. (CA) | 1991-07-02 | — | — | US | claimed |
| CN-1037651-A | DRUG ADSORBATES | GLAXO GROUP LTD (GB) | 1989-12-06 | — | — | CN | claimed |
| US-4672133-A | CRYSTALLIZATION UNDER CONTROLLED CONDITIONS | GLAXO GROUP LIMITED (GB) | 1987-06-09 | — | — | US | claimed |
| US-4521431-A | HISTAMINE H2-ANTAGHONISTS, ANTIULCER, ANTIALLERGEN, AND ANTINFLAMMATORY AGENT | GLAXO GROUP LIMITED (GB) | 1985-06-04 | — | — | US | claimed |