Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ranitidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 known ✓ | P25021 | 1/20 | 0.98 |
| ▸ | RAD52 | P43351 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | ACHE | P22303 | 15/20 | 0.98 |
| ▸ | MEN1 | O00255 | 1/20 | 0.98 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.98 |
| ▸ | LMNA | P02545 | 1/20 | 0.98 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.98 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.98 |
| ▸ | TSHR | P16473 | 1/20 | 0.98 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.98 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.98 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.98 |
| ▸ | ATP4A | P20648 | 1/20 | 0.98 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.98 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.98 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.98 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ranitidine SCHEMBL5928192 | 1.00 | RAD52 (1.00) | RAD52MAPTBLMACHEMEN1 | |
| Ranitidine SCHEMBL33299 | 1.00 | RAD52 (1.00) | RAD52MAPTBLMACHEMEN1 | |
| Ranitidine SCHEMBL33298 | 1.00 | RAD52 (1.00) | RAD52MAPTBLMACHEMEN1 | |
| Ranitidine SCHEMBL8819146 | 1.00 | RAD52 (1.00) | RAD52MAPTBLMACHEMEN1 | |
| Ranitidine SCHEMBL2228178 | 0.99 | RAD52 (0.98) | RAD52MAPTBLMACHEMEN1 | |
| Ranitidine SCHEMBL824 | 0.99 | ACHE (1.00) | RAD52MAPTBLMACHEMEN1 | |
| Ranitidine SCHEMBL8594797 | 0.99 | ACHE (1.00) | RAD52MAPTBLMACHEMEN1 | |
| Ranitidine SCHEMBL8796367 | 0.99 | ACHE (1.00) | RAD52MAPTBLMACHEMEN1 | |
| Ranitidine SCHEMBL825 | 0.99 | ACHE (1.00) | RAD52MAPTBLMACHEMEN1 | |
| Ranitidine SCHEMBL826 | 0.99 | ACHE (1.00) | RAD52MAPTBLMACHEMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023679-A1 | COMPUTER THESAURUS MANAGER | GLAXO GROUP LIMITED (GB) | 2000-08-02 | — | — | EP | disclosed |
| WO-1999021110-A1 | COMPUTER THESAURUS MANAGER | GLAXO GROUP LTD. (GB) | 1999-04-29 | — | — | WO | disclosed |