Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | MYC | P01106 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11489446 | 0.84 | TSHR (0.71) | TSHRKDM4EPOLBMYCALDH1A1 | |
| SCHEMBL11476044 | 0.82 | TSHR (0.71) | TSHRKDM4EPOLBMYCALDH1A1 | |
| SCHEMBL11475735 | 0.82 | TSHR (0.71) | TSHRKDM4EPOLBMYCALDH1A1 | |
| SCHEMBL11482821 | 0.76 | TSHR (0.56) | TSHRKDM4EPOLBALDH1A1LMNA | |
| SCHEMBL11473835 | 0.75 | TSHR (0.55) | TSHRKDM4EMYCALDH1A1LMNA | |
| SCHEMBL11476693 | 0.75 | TSHR (0.55) | TSHRKDM4EPOLBALDH1A1LMNA | |
| SCHEMBL31540617 | 0.74 | L3MBTL1 (0.52) | ALDH1A1LMNASMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL11563775 | 0.74 | TSHR (0.54) | TSHRKDM4EMYCALDH1A1LMNA | |
| SCHEMBL8481561 | 0.74 | MYC (0.56) | TSHRKDM4EPOLBMYCALDH1A1 | |
| SCHEMBL2119910 | 0.73 | ALDH1A1 (0.62) | TSHRKDM4EPOLBALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144714-A1 | DERIVATIVES OF IMIDAZO PYRIMIDO AND DIAZEPINE PYRIMIDINE-DIONE, AND USE THEREOF AS A DRUG | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2010-06-10 | — | — | US | disclosed |
| EP-2129675-A2 | DERIVATIVES OF IMIDAZO, PYRIMIDO AND DIAZEPINE PYRIMIDINE-DIONE, AND USE THEREOF AS A DRUG | IPSEN PHARMA S.A.S. (FR) | 2009-12-09 | — | — | EP | disclosed |
| WO-2008090286-A2 | DERIVATIVES OF IMIDAZO, PYRIMIDO AND DIAZEPINE PYRIMIDINE-DIONE, AND USE THEREOF AS A DRUG | IPSEN PHARMA S.A.S. (FR) | 2008-07-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144714-A1 | DERIVATIVES OF IMIDAZO PYRIMIDO AND DIAZEPINE PYRIMIDINE-DIONE, AND USE THEREOF AS A DRUG | CNR1, CNR2, TBXA2R | TSHR 503/4885KDM4E 1891/4885POLB 3933/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.