Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.62 |
| ▸ | HCAR2 | Q8TDS4 | 8/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL11785039 | 1.00 | TSHR (0.62) | TSHRHCAR2HPGDALDH1A1TP53 | |
| Fumaric Acid SCHEMBL25222500 | 0.95 | TSHR (0.56) | TSHRHCAR2HPGDALDH1A1TP53 | |
| Acrylic Acid SCHEMBL9636972 | 0.92 | TSHR (0.67) | TSHRHCAR2HPGDALDH1A1TP53 | |
| Crotonic Acid SCHEMBL27650753 | 0.91 | TSHR (0.56) | TSHRHCAR2HPGDALDH1A1TP53 | |
| SCHEMBL27800525 | 0.90 | — | — | |
| SCHEMBL27821519 | 0.90 | — | — | |
| SCHEMBL33585 | 0.90 | — | — | |
| SCHEMBL182315 | 0.88 | HCAR2 (0.57) | TSHRHCAR2ALDH1A1TP53MAPT | |
| SCHEMBL2808163 | 0.88 | HCAR2 (0.57) | TSHRHCAR2ALDH1A1TP53MAPT | |
| SCHEMBL182314 | 0.88 | HCAR2 (0.57) | TSHRHCAR2ALDH1A1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110198964-A | Carboxylic acid-modified nitrile copolymer latex, method for producing same, latex composition for dip molding comprising same, and article | 株式会社LG化学 | 2019-09-03 | — | — | CN | disclosed |
| CN-106164160-A | Rubber composition | 株式会社可乐丽 | 2016-11-23 | — | — | CN | disclosed |
| CN-106068302-A | Rubber composition | 株式会社可乐丽 | 2016-11-02 | — | — | CN | disclosed |
| US-8393391-B2 | Dry cement formulation for cementing holes in the earth | AKZO NOBEL N.V. (NL) | 2013-03-12 | — | — | US | disclosed |
| US-20100139920-A1 | DRY CEMENT FORMULATION FOR CEMENTING HOLES IN THE EARTH | AKZO NOBEL COATINGS INTERNATIONAL B.V. (NL) | 2010-06-10 | — | — | US | disclosed |
| US-3940349-A | Compositions and process for making rigid plastic foams of modified vinyl ester resins and silicone compounds | THE DOW CHEMICAL COMPANY (US) | 1976-02-24 | — | — | US | disclosed |