Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.44 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.44 |
| ▸ | PRKX | P51817 | 1/20 | 0.44 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.44 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.44 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.41 |
| ▸ | MME | P08473 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3329879 | 0.90 | MAPK1 (0.43) | ROCK2ROCK1MAPK1PRKACAPIN1 | |
| SCHEMBL3329927 | 0.85 | MEN1 (0.37) | MAPK1HDAC1HDAC6MMP2MMP9 | |
| SCHEMBL3335485 | 0.84 | ROCK1 (0.49) | ROCK2ROCK1MAPK1RPS6KA5RPS6KA4 | |
| SCHEMBL1529840 | 0.76 | MAPK1 (0.40) | ROCK2ROCK1MAPK1PRKACARAB9A | |
| SCHEMBL3330630 | 0.74 | ROCK1 (0.52) | ROCK2ROCK1MAPK1PRKACAGSK3B | |
| SCHEMBL16165445 | 0.73 | ALDH1A1 (0.50) | MAPK1HDAC1HDAC7L3MBTL1 | |
| SCHEMBL14114794 | 0.71 | ROCK2 (0.43) | ROCK2ROCK1MAPK1RPS6KA5RPS6KA4 | |
| SCHEMBL1529621 | 0.71 | ROCK2 (0.43) | ROCK2ROCK1MAPK1RPS6KA5RPS6KA4 | |
| SCHEMBL12767856 | 0.70 | CIT (0.42) | ROCK2ROCK1MAPK1PRKACA | |
| SCHEMBL3328881 | 0.69 | AKT1 (0.41) | ROCK2ROCK1MAPK1HDAC1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8338434-B2 | Inhibitors of Akt activity | GLAXOSMITHKLINE LLC (US) | 2012-12-25 | — | — | US | disclosed |
| US-20100137338-A1 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137338-A1 | INHIBITORS OF Akt ACTIVITY | PI4KB, AKT3, AKT2 | ROCK2 505/4885ROCK1 414/4885MAPK1 80/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.