Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.53 |
| ▸ | MYC | P01106 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6282188 | 0.77 | PDE7A (0.63) | ALDH1A1KMT2APDE7AMEN1ALOX12 | |
| SCHEMBL1708270 | 0.77 | ALDH1A1 (0.48) | ALDH1A1KMT2ASMN1; SMN2KDM4ETSHR | |
| SCHEMBL2313957 | 0.76 | MYC (0.56) | ALDH1A1KMT2ASMN1; SMN2TSHRMEN1 | |
| SCHEMBL6284203 | 0.76 | PDE7A (0.61) | ALDH1A1KMT2APDE7AMEN1ALOX12 | |
| SCHEMBL6280728 | 0.74 | PDE7A (0.63) | ALDH1A1KMT2ASMN1; SMN2KDM4EPDE7A | |
| SCHEMBL18239972 | 0.74 | HTT (0.67) | ALDH1A1KMT2ASMN1; SMN2KDM4EPDE7A | |
| SCHEMBL7652250 | 0.74 | SMN1; SMN2 (0.67) | ALDH1A1KMT2ASMN1; SMN2KDM4ETSHR | |
| SCHEMBL11926706 | 0.72 | MYC (0.66) | ALDH1A1KMT2ASMN1; SMN2KDM4ETSHR | |
| SCHEMBL6286214 | 0.71 | PDE7A (0.62) | ALDH1A1KMT2AKDM4EPDE7AMEN1 | |
| SCHEMBL6278489 | 0.71 | KMT2A (0.75) | ALDH1A1KMT2ASMN1; SMN2KDM4EPDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144714-A1 | DERIVATIVES OF IMIDAZO PYRIMIDO AND DIAZEPINE PYRIMIDINE-DIONE, AND USE THEREOF AS A DRUG | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2010-06-10 | — | — | US | disclosed |
| EP-2129675-A2 | DERIVATIVES OF IMIDAZO, PYRIMIDO AND DIAZEPINE PYRIMIDINE-DIONE, AND USE THEREOF AS A DRUG | IPSEN PHARMA S.A.S. (FR) | 2009-12-09 | — | — | EP | disclosed |
| WO-2008090286-A2 | DERIVATIVES OF IMIDAZO, PYRIMIDO AND DIAZEPINE PYRIMIDINE-DIONE, AND USE THEREOF AS A DRUG | IPSEN PHARMA S.A.S. (FR) | 2008-07-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144714-A1 | DERIVATIVES OF IMIDAZO PYRIMIDO AND DIAZEPINE PYRIMIDINE-DIONE, AND USE THEREOF AS A DRUG | CNR1, CNR2, TBXA2R | ALDH1A1 1911/4885KMT2A 2230/4885SMN1; SMN2 4012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.