Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 3/20 | 0.52 |
| ▸ | PPARG | P37231 | 16/20 | 0.41 |
| ▸ | PPARA | Q07869 | 6/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL334000 | 0.94 | PTGES (0.48) | PTGESPPARGPPARACYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL333805 | 0.90 | PTGES (0.55) | PTGESPPARGPPARA | |
| SCHEMBL3002045 | 0.88 | PTGES (0.59) | PTGESPPARGPPARA | |
| SCHEMBL333586 | 0.85 | PTGES (0.51) | PTGESPPARGPPARACYP2C9CYP2C19 | |
| SCHEMBL3012072 | 0.85 | PTGES (0.51) | PTGESPPARGPPARA | |
| SCHEMBL3007629 | 0.80 | PTGES (0.56) | PTGESPPARGPPARA | |
| SCHEMBL334001 | 0.79 | PTGES (0.47) | PTGESPPARGPPARACYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL333803 | 0.79 | PTGES (0.57) | PTGESPPARGPPARA | |
| Hydrochloric Acid SCHEMBL3007126 | 0.79 | PTGES (0.53) | PTGESPPARGPPARA | |
| Hydrochloric Acid SCHEMBL3007119 | 0.79 | PTGES (0.53) | PTGESPPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8097623-B2 | 1-Aryl-or heteroaryl-3-aryl-or heteroarylindole-2-carboxylic acids or esters: e.g., 5-(4-tert-Butylphenyl)-1,3-bis(4-isopropoxyphenyl)-indole-2-carboxylic acid; inhibition of the activity of microsomal prostaglandin E synthase-1, leukotriene C4 and/or 5-lipoxygenase-activating protein; analgesics | BIOLIPOX AB (SE) | 2012-01-17 | — | — | US | disclosed |
| EP-1841735-B1 | INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION | BIOLIPOX AB (SE) | 2011-03-09 | — | — | EP | disclosed |
| US-20090076004-A1 | Indoles Useful in the Treatment of Inflammation | BIOLIPOX AB (SE) | 2009-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090076004-A1 | Indoles Useful in the Treatment of Inflammation | IDO1, IDO2, AREG | PTGES 34/4885PPARG 2451/4885PPARA 3590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.