Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Betazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 known ✓ | P25021 | 3/20 | 1.00 |
| ▸ | USP2 | O75604 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | HRH1 | P35367 | 6/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | AKT2 | P31751 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Betazole SCHEMBL157156 | 1.00 | — | — | |
| Betazole SCHEMBL1237745 | 0.98 | — | — | |
| Betazole SCHEMBL1649674 | 0.98 | HRH2 (0.95) | HRH2USP2LMNAHRH1HRH4 | |
| Betazole SCHEMBL29633745 | 0.98 | HRH2 (0.95) | HRH2USP2LMNAHRH1HRH4 | |
| SCHEMBL4711257 | 0.86 | — | — | |
| Betazole SCHEMBL3336046 | 0.82 | USP2 (0.68) | HRH2USP2LMNAHRH1HRH4 | |
| SCHEMBL2183872 | 0.80 | — | — | |
| SCHEMBL4222977 | 0.76 | — | — | |
| SCHEMBL21721708 | 0.76 | — | — | |
| Bromide SCHEMBL10400923 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130059878-A1 | TREATMENT OF DISEASES MODULATED BY A H4 RECEPTOR AGONIST | LORIA EMILE (US) | 2013-03-07 | — | — | US | disclosed |
| US-8207188-B2 | Treatment of diseases modulated by a H4 receptor agonist | NICOLAOU MICHALIS (US) | 2012-06-26 | — | — | US | disclosed |
| US-20100144718-A1 | TREATMENT OF DISEASES MODULATED BY A H4 RECEPTOR AGONIST | NICOLAOU MICHALIS | 2010-06-10 | — | — | US | disclosed |