SCHEMBL333734

SCHEMBL333734

Nc1ccccc1C(=O)c1ccc(F)cc1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.71
GAA P10253 1/20 0.71
CA1 P00915 1/20 0.57
CA2 P00918 1/20 0.57
CA9 Q16790 1/20 0.57
HSD11B1 P28845 1/20 0.51
MAPK14 Q16539 3/20 0.48
POLB P06746 1/20 0.47
NPC1 O15118 2/20 0.46
TSHR P16473 1/20 0.46
MAPK1 P28482 1/20 0.46
LTA4H P09960 1/20 0.46
MAPK13 O15264 2/20 0.45
MAPK12 P53778 2/20 0.45
MAPK11 Q15759 2/20 0.45
CES2 O00748 1/20 0.45
CES1 P23141 1/20 0.45
TP53 P04637 1/20 0.45
ALOX15 P16050 1/20 0.45
HSD17B10 Q99714 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29558763 1.00 MAPT (0.71) MAPTGAACA1CA2CA9
SCHEMBL756920 0.90 MAPT (0.59) MAPTGAACA1CA2CA9
SCHEMBL8374908 0.90 MAPT (0.87) MAPTGAACA1CA2CA9
SCHEMBL1754308 0.86 AKR1C3 (0.58) MAPTCA1CA2NPC1TSHR
SCHEMBL7743794 0.85 MAPT (0.52) MAPTGAACA1CA2CA9
SCHEMBL10948187 0.85 KEAP1 (0.63) MAPTGAAMAPK14POLBNPC1
SCHEMBL3178977 0.84 MAPT (0.77) MAPTGAACA1CA2CA9
SCHEMBL29364222 0.84 MAPT (0.77) MAPTGAACA1CA2CA9
SCHEMBL3138398 0.84 MAPT (0.77) MAPTGAACA1CA2CA9
Benzene SCHEMBL28318261 0.84 AKR1C3 (0.61) MAPTGAAMAPK14NPC1LTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 369 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116947922-A Synthesis process of pitavastatin intermediate 江苏福瑞康泰药业有限公司 2023-10-27 CN claimed
CN-110606839-B Green synthesis method of polysubstituted quinazoline derivative 南方医科大学 2021-10-08 CN claimed
CN-109574863-B Synthesis method of 2-amino-4' -fluoro-benzophenone 安徽省庆云医药股份有限公司 2021-09-14 CN claimed
CN-107673982-B Preparation method of 2-amino-4' -fluoro-benzophenone 安徽省庆云医药股份有限公司 2020-07-24 CN claimed
CN-107652192-B Method for preparing 2-amino-4' -fluoro-benzophenone 安徽省庆云医药股份有限公司 2020-07-24 CN claimed
EP-3470491-A1 PHOSPHORUS-CONTAINING STABILIZERS FOR FLUOROOLEFINS The Chemours Company FC, LLC (US) 2019-04-17 EP claimed
EP-2410032-B1 Phosphorus-containing stabilizers for fluoroolefins CHEMOURS CO FC LLC (US) 2018-11-14 EP claimed
US-20170362483-A1 EPOXIDE AND FLUORINATED EPOXIDE STABILIZERS FOR FLUOROOLEFINS THE CHEMOURS COMPANY FC, LLC 2017-12-21 US claimed
EP-2420546-B1 Terephthalate stabilizers for fluoroolefins CHEMOURS CO FC LLC (US) 2017-04-26 EP claimed
EP-2598484-B1 PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES FOR THE SYNTHESIS OF STATINS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF LEK PHARMACEUTICALS (SI) 2016-06-29 EP claimed
WO-2008027519-A1 OXETANE STABILIZERS FOR FLUOROOLEFINS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2008-03-06 WO claimed
WO-2008027596-A2 BENZOPHENONE DERIVATIVE STABILIZERS FOR FLUOROOLEFINS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2008-03-06 WO claimed
WO-2008027512-A2 FUNCTIONALIZED PERFLUOROPOLYETHER STABILIZERS FOR FLUOROOLEFINS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2008-03-06 WO claimed
WO-2008027594-A2 PHENOL STABILIZERS FOR FLUOROOLEFINS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2008-03-06 WO claimed
WO-2008027518-A2 ASCORBIC ACID, TEREPHTHALATE, OR NITROMETHANE STABILIZERS FOR FLUOROOLEFINS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2008-03-06 WO claimed
WO-2008027513-A2 ARYL-ALKYL ETHER, POLYOXYALKYLATED AROMATIC, AND ALKYLATED AROMATIC STABILIZERS FOR FLUOROOLEFINS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2008-03-06 WO claimed
WO-2007126760-A2 COMPOSITIONS COMPRISING IODOTRIFLUOROMETHANE AND STABILIZERS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2007-11-08 WO claimed
US-6841681-B2 Process for producing quinoline carboxyaldehyde derivative and intermediate thereof NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2005-01-11 US claimed
US-20040077866-A1 Process for producing quinoline carboxyaldehyde derivative and intermediate thereof NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2004-04-22 US claimed
EP-1361215-A1 PROCESS FOR PRODUCING QUINOLINE CARBOXYALDEHYDE DERIVATIVE AND INTERMEDIATE THEREOF Nissan Chemical Industries, Ltd. (JP) 2003-11-12 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040077866-A1 Process for producing quinoline carboxyaldehyde derivative and intermediate thereof CPNE4, CYP3A4, CYP4B1 MAPT 2706/4885GAA 447/4885CA1 1949/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.