Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CFTR | P13569 | 1/20 | 0.45 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL333734 | 0.90 | MAPT (0.71) | MAPTGAACA1CA2CA9 | |
| SCHEMBL29558763 | 0.90 | MAPT (0.71) | MAPTGAACA1CA2CA9 | |
| SCHEMBL8374908 | 0.81 | MAPT (0.87) | MAPTGAACA1CA2CA9 | |
| SCHEMBL6342603 | 0.81 | CA1 (0.68) | MAPTGAACA1CA2CA9 | |
| SCHEMBL11844632 | 0.78 | MAPT (0.49) | MAPTGAACA1CA2CA9 | |
| SCHEMBL1754308 | 0.77 | AKR1C3 (0.58) | MAPTCA1CA2KMT2AHSD17B10 | |
| SCHEMBL20491087 | 0.77 | KMT2A (0.77) | MAPTBDKRB1KMT2AHSD17B10ALDH1A1 | |
| SCHEMBL7743794 | 0.77 | MAPT (0.52) | MAPTGAACA1CA2CA9 | |
| SCHEMBL10948187 | 0.76 | KEAP1 (0.63) | MAPTGAAMAPK14NPC1HTT | |
| SCHEMBL4639277 | 0.76 | MAPT (0.71) | MAPTGAACA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1361215-B1 | PROCESS FOR PRODUCING QUINOLINE CARBOXYALDEHYDE DERIVATIVE AND INTERMEDIATE THEREOF | NISSAN CHEMICAL IND LTD (JP) | 2012-03-21 | — | — | EP | disclosed |
| EP-1375487-B1 | PROCESS FOR PRODUCING QUINOLINE-3-CARBOXYLIC ACID COMPOUNDS | SUMITOMO CHEMICAL CO (JP) | 2011-08-24 | — | — | EP | disclosed |
| US-6909003-B2 | Process for the manufacture of organic compounds | NOVARTIS AG (CH) | 2005-06-21 | — | — | US | disclosed |
| US-6852862-B2 | Process for producing quinoline-3-carboxylic acid compound | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2005-02-08 | — | — | US | disclosed |
| US-6841681-B2 | Process for producing quinoline carboxyaldehyde derivative and intermediate thereof | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2005-01-11 | — | — | US | disclosed |
| US-20040077866-A1 | Process for producing quinoline carboxyaldehyde derivative and intermediate thereof | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2004-04-22 | — | — | US | disclosed |
| US-20040073034-A1 | Process for producing quinoline-3-carboxylic acid compound | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2004-04-15 | — | — | US | disclosed |
| EP-1375487-A1 | PROCESS FOR PRODUCING QUINOLINE-3-CARBOXYLIC ACID COMPOUND | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 2004-01-02 | — | — | EP | disclosed |
| US-20030233001-A1 | Process for the manufacture of organic compounds | NOVARTIS AG (CH) | 2003-12-18 | — | — | US | disclosed |
| EP-1361215-A1 | PROCESS FOR PRODUCING QUINOLINE CARBOXYALDEHYDE DERIVATIVE AND INTERMEDIATE THEREOF | Nissan Chemical Industries, Ltd. (JP) | 2003-11-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077866-A1 | Process for producing quinoline carboxyaldehyde derivative and intermediate thereof | CPNE4, CYP3A4, CYP4B1 | MAPT 2706/4885GAA 447/4885CA1 1949/4885 |
| US-20030233001-A1 | Process for the manufacture of organic compounds | CYP11B2, CYP11B1, HSD17B12 | MAPT 3765/4885GAA 1417/4885CA1 599/4885 |
| US-20040073034-A1 | Process for producing quinoline-3-carboxylic acid compound | ADH1C, ADH5, CBR3 | MAPT 3998/4885GAA 2950/4885CA1 855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.