Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | HTR1A | P08908 | 3/20 | 0.48 |
| ▸ | HTR2C | P28335 | 3/20 | 0.48 |
| ▸ | RBP4 | P02753 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3340471 | 0.86 | MAPT (0.68) | POLBMAPTMAPK1TSHRSMN1; SMN2 | |
| SCHEMBL13431594 | 0.83 | POLB (1.00) | POLBMAPTMAPK1SMN1; SMN2HTT | |
| SCHEMBL13164999 | 0.83 | LMNA (0.58) | POLBMAPTMAPK1RBP4TSHR | |
| SCHEMBL3339972 | 0.82 | MAPT (0.65) | POLBMAPTMAPK1TSHRSMN1; SMN2 | |
| SCHEMBL19001385 | 0.79 | HTR2C (0.58) | POLBMAPTHTR1AHTR2CSMN1; SMN2 | |
| SCHEMBL1901285 | 0.77 | SMN1; SMN2 (0.51) | POLBMAPTMAPK1TSHRSMN1; SMN2 | |
| SCHEMBL1902859 | 0.76 | ACHE (0.48) | POLBMAPTMAPK1TSHRSMN1; SMN2 | |
| SCHEMBL1899118 | 0.76 | KMT2A (0.53) | POLBMAPTMAPK1TSHRSMN1; SMN2 | |
| SCHEMBL18997666 | 0.72 | MEN1 (0.52) | POLBMAPTMAPK1HTR1AHTR2C | |
| SCHEMBL1904253 | 0.72 | KMT2A (0.59) | POLBMAPTMAPK1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100063047-A1 | AMINOPYRIMIDINE INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063047-A1 | AMINOPYRIMIDINE INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | HRH4, HRH2, HRH3 | POLB 2075/4885MAPT 2488/4885MAPK1 3238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.