Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.39 |
| ▸ | AR | P10275 | 4/20 | 0.39 |
| ▸ | KHK | P50053 | 1/20 | 0.39 |
| ▸ | PGK1 | P00558 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.35 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17520012 | 0.92 | ALDH1A1 (0.46) | ALDH1A1TRPV4ARKHKPGK1 | |
| SCHEMBL832660 | 0.83 | TRPV4 (0.45) | ALDH1A1TRPV4ARKHKCYP11B2 | |
| SCHEMBL3336692 | 0.82 | ALDH1A1 (0.51) | ALDH1A1TRPV4ARKHKPGK1 | |
| SCHEMBL18179223 | 0.82 | TRPV4 (0.45) | ALDH1A1TRPV4ARPGK1CYP11B2 | |
| SCHEMBL23730334 | 0.82 | TRPV4 (0.46) | TRPV4KHKCYP11B2EGLN2TSHR | |
| SCHEMBL7931517 | 0.80 | ALDH1A1 (0.46) | ALDH1A1TRPV4ARKHKPGK1 | |
| SCHEMBL10257221 | 0.80 | TRPV4 (0.40) | TRPV4KHKCYP11B2EGLN2TSHR | |
| SCHEMBL862662 | 0.80 | TRPV4 (0.50) | TRPV4KHKCYP11B2EGLN2TSHR | |
| SCHEMBL30583466 | 0.80 | TRPV4 (0.50) | TRPV4KHKCYP11B2EGLN2TSHR | |
| SCHEMBL28831695 | 0.79 | ALDH1A1 (0.42) | ALDH1A1TRPV4ARKHKPGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8592452-B2 | Cyclic amine compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-11-26 | — | — | US | disclosed |
| US-20100152236-A1 | Cyclic amine compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-06-17 | — | — | US | disclosed |
| US-20100152236-A1 | Cyclic amine compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-06-17 | — | — | US | disclosed |
| US-20100152236-A1 | Cyclic amine compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-06-17 | — | — | US | disclosed |
| EP-1911743-A1 | CYCLIC AMINE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2008-04-16 | — | — | EP | disclosed |
| EP-1911743-A1 | CYCLIC AMINE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2008-04-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152236-A1 | Cyclic amine compound | AR, FSHR, NR5A1 | ALDH1A1 2416/4885TRPV4 3837/4885AR 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.