Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | PLD2 | O14939 | 6/20 | 0.42 |
| ▸ | PLD1 | Q13393 | 6/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3339072 | 0.91 | PARP1 (0.54) | PARP1HTR3AALDH1A1HSD17B10LMNA | |
| Trifluoroacetic Acid SCHEMBL3343890 | 0.78 | PARP1 (0.54) | PARP1HTR3AALDH1A1HSD17B10LMNA | |
| Trifluoroacetic Acid SCHEMBL3339025 | 0.78 | POLB (0.51) | PARP1KDM4EALDH1A1HSD17B10LMNA | |
| SCHEMBL3340742 | 0.76 | ACHE (0.57) | — | |
| SCHEMBL3339450 | 0.72 | PARP1 (0.43) | PARP1KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3337044 | 0.72 | MEN1 (0.55) | KDM4EALDH1A1MAPTGAASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL3338854 | 0.71 | KMT2A (0.44) | PARP1KDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL3338476 | 0.71 | PARP1 (0.47) | PARP1KDM4EALDH1A1HSD17B10GAA | |
| SCHEMBL3344069 | 0.70 | PARP1 (0.42) | PARP1 | |
| SCHEMBL3337722 | 0.69 | BRPF1 (0.46) | PARP1HDAC8HDAC6DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100152180-A1 | 4-oxo-4,5-dihydropyrrolo[1,2-A)quinoxaline derivatives as inhibitors of poly(ADP-ribose) polymerase (PARP) | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2010-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152180-A1 | 4-oxo-4,5-dihydropyrrolo[1,2-A)quinoxaline derivatives as inhibitors of poly(ADP-ribose) polymerase (PARP) | PARP1, PARP2, PARP4 | PARP1 1/4885HDAC2 2930/4885HDAC8 2994/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.