Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | ESRRA | P11474 | 4/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | DDT | P30046 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346206 | 0.77 | KAT6A (0.46) | NPC1RAB9ASMN1; SMN2SIRT3TDP1 | |
| SCHEMBL3340257 | 0.76 | KDM4E (0.49) | NOTUMNPC1RAB9ASMN1; SMN2MIF | |
| SCHEMBL25092487 | 0.76 | NOTUM (0.50) | NOTUMNPC1RAB9ASMN1; SMN2MIF | |
| SCHEMBL3343037 | 0.73 | PDE4A (0.44) | SIRT3TDP1MAOAMAOB | |
| SCHEMBL3346133 | 0.73 | SIRT3 (0.38) | NOTUMSIRT3TDP1ALDH1A1KMT2A | |
| SCHEMBL3342457 | 0.73 | LRRK2 (0.47) | NOTUMSIRT3TDP1ALDH1A1KDM4E | |
| SCHEMBL29132957 | 0.73 | NOTUM (0.46) | NOTUMESRRAALDH1A1KDM4EKMT2A | |
| SCHEMBL31226939 | 0.72 | KMT2A (0.43) | NOTUMNPC1RAB9ASMN1; SMN2MIF | |
| SCHEMBL3344595 | 0.72 | L3MBTL1 (0.47) | SMN1; SMN2SIRT3TDP1ALDH1A1KDM4E | |
| SCHEMBL31227373 | 0.71 | KMT2A (0.44) | NOTUMNPC1RAB9ASMN1; SMN2MIF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | ROCHE PALO ALTO LLC | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | P2RY1, P2RX6, P2RX3 | NOTUM 4864/4885NPC1 1906/4885RAB9A 1850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.