Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.35 |
| ▸ | INCENP | Q9NQS7 | 4/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 3/20 | 0.32 |
| ▸ | TTK | P33981 | 3/20 | 0.32 |
| ▸ | PDE4A | P27815 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3340308 | 0.81 | BTK (0.38) | NOTUMP2RX7PIK3R2 | |
| SCHEMBL3342950 | 0.81 | BRD4 (0.43) | NOTUMPDE3BPDE3AAURKBINCENP | |
| SCHEMBL14955413 | 0.80 | NOTUM (0.43) | NOTUMPDE3BPDE3AP2RX7RPS6KA3 | |
| SCHEMBL3344619 | 0.78 | LMNA (0.50) | PDE3BPDE3AAURKBINCENPP2RX7 | |
| SCHEMBL3348222 | 0.76 | BRD4 (0.36) | PDE3BPDE3AAURKBINCENPP2RX7 | |
| SCHEMBL3094563 | 0.75 | NOTUM (0.56) | NOTUMPDE3BPDE3AP2RX7PIK3CB | |
| SCHEMBL2326304 | 0.75 | NOTUM (0.40) | NOTUMPDE3BPDE3AAURKBINCENP | |
| SCHEMBL2487299 | 0.71 | RXRB (0.43) | NOTUMP2RX7LMNATSHRKDM4E | |
| SCHEMBL5070318 | 0.70 | KDR (0.41) | PDE3BPDE3AAURKBINCENPLMNA | |
| SCHEMBL17151369 | 0.70 | SCN4A (0.46) | NOTUMP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | ROCHE PALO ALTO LLC | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | P2RY1, P2RX6, P2RX3 | NOTUM 4864/4885PDE3B 1330/4885PDE3A 1521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.