Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenmetrazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.72 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.72 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.72 |
| ▸ | HTR2B | P41595 | 1/20 | 0.72 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 5/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenmetrazine SCHEMBL4385399 | 0.87 | SLC6A2 (0.65) | SLC6A2SLC6A3ADRA1AHTR2BCHRNA7 | |
| Phenmetrazine SCHEMBL33984 | 0.85 | SLC6A2 (1.00) | SLC6A2SLC6A3ADRA1AHTR2BCHRNA7 | |
| Phenmetrazine SCHEMBL15159761 | 0.85 | SLC6A2 (1.00) | SLC6A2SLC6A3ADRA1AHTR2BCHRNA7 | |
| Phenmetrazine SCHEMBL15154744 | 0.85 | SLC6A2 (1.00) | SLC6A2SLC6A3ADRA1AHTR2BCHRNA7 | |
| Phenmetrazine SCHEMBL265002 | 0.85 | SLC6A2 (1.00) | SLC6A2SLC6A3ADRA1AHTR2BCHRNA7 | |
| Phenmetrazine SCHEMBL15159760 | 0.85 | SLC6A2 (1.00) | SLC6A2SLC6A3ADRA1AHTR2BCHRNA7 | |
| Phenmetrazine SCHEMBL8094204 | 0.85 | SLC6A2 (1.00) | SLC6A2SLC6A3ADRA1AHTR2BCHRNA7 | |
| Phenmetrazine SCHEMBL22462307 | 0.83 | SLC6A2 (0.96) | SLC6A2SLC6A3ADRA1AHTR2BCHRNA7 | |
| Phenmetrazine SCHEMBL121536 | 0.83 | SLC6A2 (0.96) | SLC6A2SLC6A3ADRA1AHTR2BCHRNA7 | |
| Phenmetrazine SCHEMBL3341647 | 0.82 | SLC6A2 (0.81) | SLC6A2SLC6A3ADRA1AHTR2BCHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121029-A2 | PRODRUGS AND METHODS OF MAKING AND USING THE SAME | Neurogesx, Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| US-20080318905-A1 | Prodrugs and methods of making and using the same | NEUROGESX, INC. | 2008-12-25 | — | — | US | disclosed |
| WO-2008070149-A2 | PRODRUGS AND METHODS OF MAKING AND USING THE SAME | NEUROGESX, INC. (US) | 2008-06-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318905-A1 | Prodrugs and methods of making and using the same | NAPEPLD, CES2, MTAP | SLC6A2 106/4885SLC6A3 153/4885ADRA1A 1583/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.