Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLD1 | Q13393 | 1/20 | 0.62 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | NCF1 | P14598 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.48 |
| ▸ | HTR3B | O95264 | 2/20 | 0.48 |
| ▸ | HTR3A | P46098 | 2/20 | 0.48 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.48 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30080727 | 0.84 | HTR3A (0.64) | ADRB1ADRB2NCF1ALDH1A1CYP2C9 | |
| SCHEMBL255186 | 0.84 | HTR3A (0.64) | ADRB1ADRB2NCF1ALDH1A1CYP2C9 | |
| Hydrochloric Acid SCHEMBL19385628 | 0.82 | HTR3A (0.62) | ADRB1ADRB2NCF1ALDH1A1CYP2C9 | |
| SCHEMBL893565 | 0.79 | PLD1 (1.00) | PLD1ADRB1HSD17B10ALDH1A1CYP2C9 | |
| SCHEMBL7900 | 0.79 | PLD1 (1.00) | PLD1ADRB1HSD17B10ALDH1A1CYP2C9 | |
| SCHEMBL29400889 | 0.79 | PLD1 (1.00) | PLD1ADRB1HSD17B10ALDH1A1CYP2C9 | |
| Hydrochloric Acid SCHEMBL4165242 | 0.78 | PLD1 (0.96) | PLD1HSD17B10ALDH1A1CYP2C9CYP2C19 | |
| Ammonia Solution, Strong SCHEMBL17926100 | 0.78 | PLD1 (0.96) | PLD1ADRB1HSD17B10ALDH1A1CYP2C9 | |
| Hydrochloric Acid SCHEMBL27481639 | 0.78 | PLD1 (0.96) | PLD1HSD17B10ALDH1A1CYP2C9CYP2C19 | |
| Piperazine SCHEMBL27920772 | 0.78 | PLD1 (0.96) | PLD1ADRB1HSD17B10ALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100063047-A1 | AMINOPYRIMIDINE INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063047-A1 | AMINOPYRIMIDINE INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | HRH4, HRH2, HRH3 | PLD1 3485/4885ADRB1 993/4885ADRB2 882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.