Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.49 |
| ▸ | PDE4A | P27815 | 2/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31269796 | 0.91 | GPR119 (0.54) | GPR119PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL215713 | 0.85 | GPR119 (0.57) | GPR119PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL31270222 | 0.85 | GPR119 (0.48) | GPR119PDE4BHRH3CHEK2 | |
| Hydrochloric Acid SCHEMBL9013879 | 0.84 | GPR119 (0.56) | GPR119PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL848331 | 0.83 | GPR119 (0.57) | GPR119PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL3342725 | 0.82 | GPR119 (0.61) | GPR119PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7404751 | 0.82 | GPR119 (0.56) | GPR119PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7406884 | 0.82 | GPR119 (0.56) | GPR119PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL24117863 | 0.82 | GPR119 (0.56) | GPR119HRH3CHEK2EPHX2DPP4 | |
| SCHEMBL13637112 | 0.81 | GPR119 (0.58) | GPR119PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |