Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 15/20 | 0.61 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.44 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.44 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.44 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.44 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.44 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.44 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.44 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.44 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.44 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.44 |
| ▸ | CACNB2 | Q08289 | 1/20 | 0.44 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.44 |
| ▸ | CACNA1E | Q15878 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3344956 | 0.88 | GPR119 (0.64) | GPR119CACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL20137797 | 0.87 | GPR119 (0.67) | GPR119NPBWR1MCHR1CACNB4CACNA1A | |
| SCHEMBL23311669 | 0.84 | GPR119 (0.67) | GPR119NPBWR1MCHR1CACNB4CACNA1A | |
| SCHEMBL21607020 | 0.83 | GPR119 (0.58) | GPR119NPBWR1MCHR1 | |
| SCHEMBL30263276 | 0.83 | GPR119 (0.58) | GPR119NPBWR1MCHR1 | |
| SCHEMBL7401143 | 0.83 | GPR119 (0.62) | GPR119NPBWR1MCHR1 | |
| SCHEMBL2548353 | 0.82 | GPR119 (0.65) | GPR119NPBWR1MCHR1CACNB4CACNA1A | |
| SCHEMBL30201903 | 0.82 | GPR119 (0.65) | GPR119NPBWR1MCHR1CACNB4CACNA1A | |
| SCHEMBL5267887 | 0.82 | GPR119 (0.68) | GPR119NPBWR1MCHR1CACNB4CACNA1A | |
| SCHEMBL64030 | 0.81 | GPR119 (0.53) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |