Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 20/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.65 |
| ▸ | GPR183 | P32249 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14634214 | 0.84 | GPR119 (0.59) | GPR119CYP3A4CYP2C19GPR183KCNH2 | |
| SCHEMBL14648401 | 0.84 | GPR119 (0.59) | GPR119CYP3A4CYP2C19GPR183KCNH2 | |
| SCHEMBL14634213 | 0.84 | GPR119 (0.59) | GPR119CYP3A4CYP2C19GPR183KCNH2 | |
| SCHEMBL3343438 | 0.82 | GPR119 (0.58) | GPR119CYP3A4CYP2C19GPR183 | |
| SCHEMBL5823244 | 0.82 | GPR119 (0.64) | GPR119CYP3A4CYP2C19GPR183KCNH2 | |
| SCHEMBL3374622 | 0.81 | GPR119 (0.59) | GPR119CYP3A4CYP2C19GPR183 | |
| SCHEMBL390901 | 0.80 | GPR119 (0.63) | GPR119CYP3A4CYP2C19GPR183KCNH2 | |
| SCHEMBL389196 | 0.80 | GPR119 (0.63) | GPR119CYP3A4CYP2C19GPR183KCNH2 | |
| SCHEMBL390154 | 0.79 | GPR119 (0.72) | GPR119CYP3A4CYP2C19GPR183KCNH2 | |
| SCHEMBL15312654 | 0.79 | GPR119 (1.00) | GPR119CYP3A4CYP2C19KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |