Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.43 |
| ▸ | CHUK | O15111 | 4/20 | 0.41 |
| ▸ | IKBKB | O14920 | 3/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 3/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | MAP2 | P11137 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.35 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3344611 | 0.84 | BTK (0.46) | BTKCHUKIKBKBP2RX7CDC7 | |
| SCHEMBL3340308 | 0.83 | BTK (0.38) | BTKCHUKIKBKBP2RX7NOTUM | |
| SCHEMBL3342950 | 0.80 | BRD4 (0.43) | P2RX7PARP1NOTUMCASP1IDO1 | |
| SCHEMBL3344631 | 0.76 | P2RX7 (0.40) | CHUKIKBKBP2RX7CDC7CASP1 | |
| SCHEMBL14955413 | 0.72 | NOTUM (0.43) | P2RX7NOTUMIDO1 | |
| SCHEMBL15730739 | 0.72 | MKNK1 (0.40) | CHUKIKBKBCDC7CASP1ALOX5AP | |
| SCHEMBL17151369 | 0.72 | SCN4A (0.46) | BTKP2RX7NOTUMCDC7IDO1 | |
| SCHEMBL1210909 | 0.71 | HCAR2 (0.42) | BTKPARP1CDC7DGAT1 | |
| SCHEMBL3386608 | 0.71 | CHUK (0.68) | CHUKIKBKBCDC7CASP1IKBKE | |
| Hydrochloric Acid SCHEMBL30015576 | 0.71 | SCN4A (0.45) | BTKP2RX7NOTUMCDC7IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | ROCHE PALO ALTO LLC | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | P2RY1, P2RX6, P2RX3 | BTK 3512/4885CHUK 1510/4885IKBKB 2102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.