Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | GPR3 | P46089 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | GABRP | O00591 | 4/20 | 0.50 |
| ▸ | GABRD | O14764 | 4/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.50 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.50 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.50 |
| ▸ | GABRE | P78334 | 4/20 | 0.50 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.50 |
| ▸ | GABRG1 | Q8N1C3 | 4/20 | 0.50 |
| ▸ | GABRG3 | Q99928 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29472459 | 1.00 | AHR (0.55) | AHRALDH1A1GPR3HSD17B10ACHE | |
| SCHEMBL1982871 | 0.85 | GABRP (0.64) | AHRALDH1A1GABRPGABRDGABRA1 | |
| SCHEMBL23803036 | 0.78 | AHR (0.55) | AHRALDH1A1GPR3HSD17B10ACHE | |
| SCHEMBL31180481 | 0.78 | AHR (0.55) | AHRALDH1A1GPR3HSD17B10ACHE | |
| SCHEMBL13100678 | 0.78 | KIF11 (0.56) | AHRALDH1A1GPR3HSD17B10ACHE | |
| SCHEMBL17967637 | 0.77 | MAPT (0.55) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL19270254 | 0.74 | MAPT (0.51) | AHRALDH1A1GPR3HSD17B10ACHE | |
| SCHEMBL31180480 | 0.74 | GABRP (0.77) | AHRALDH1A1HSD17B10GABRPGABRD | |
| SCHEMBL12219476 | 0.73 | AHR (1.00) | AHRALDH1A1GPR3HSD17B10TOP2A | |
| SCHEMBL12219478 | 0.73 | AHR (1.00) | AHRALDH1A1GPR3HSD17B10TOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3634962-A1 | AZAINDOLE COMPOUNDS AS HISTONE METHYLTRANSFERASE INHIBITORS | Global Blood Therapeutics, Inc. (US) | 2020-04-15 | — | — | EP | disclosed |
| WO-2018226998-A1 | AZAINDOLE COMPOUNDS AS HISTONE METHYLTRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2018-12-13 | — | — | WO | disclosed |
| US-20100162416-A1 | Multi-stage stem cell carcinogenesis | STEMLIFELINE, INC. (US) | 2010-06-24 | — | — | US | disclosed |
| WO-2010037134-A2 | MULTI-STAGE STEM CELL CARCINOGENESIS | STEMLIFELINE, INC. (US) | 2010-04-01 | — | — | WO | disclosed |
| EP-0680517-B2 | METHODS AND DIAGNOSTIC KITS UTILIZING MAMMALIAN STRESS PROMOTERS TO DETERMINE TOXICITY OF A COMPOUND | HARVARD COLLEGE (US) | 2005-01-19 | — | — | EP | disclosed |
| US-20030219714-A1 | Methods and diagnostic kits utilizing mammalian stress promoters to determine toxicity of a compound | PRESIDENT AND FELLOWS OF HARVARD COLLEGE AND XENOMETRIX, INC. | 2003-11-27 | — | — | US | disclosed |
| EP-0680517-B1 | METHODS AND DIAGNOSTIC KITS UTILIZING MAMMALIAN STRESS PROMOTERS TO DETERMINE TOXICITY OF A COMPOUND | HARVARD COLLEGE (US) | 1997-11-12 | — | — | EP | disclosed |