Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 18/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 18/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3348002 | 0.88 | HCRTR1 (0.44) | HCRTR1HCRTR2 | |
| SCHEMBL3343999 | 0.87 | HCRTR1 (0.45) | HCRTR1HCRTR2RAB9AKDM4EALDH1A1 | |
| SCHEMBL3350764 | 0.84 | HCRTR1 (0.50) | HCRTR1HCRTR2 | |
| SCHEMBL2635038 | 0.83 | HCRTR1 (0.46) | HCRTR1HCRTR2 | |
| SCHEMBL3343687 | 0.82 | HCRTR1 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL2056846 | 0.79 | HCRTR1 (0.46) | HCRTR1HCRTR2 | |
| SCHEMBL980763 | 0.78 | PIN1 (0.51) | HCRTR1HCRTR2RAB9AKDM4EALDH1A1 | |
| SCHEMBL3348068 | 0.77 | HCRTR1 (0.54) | HCRTR1HCRTR2 | |
| SCHEMBL2126124 | 0.76 | HCRTR1 (0.41) | HCRTR1HCRTR2RAB9AKDM4EALDH1A1 | |
| SCHEMBL2635383 | 0.75 | HCRTR1 (0.46) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038200-A1 | OXAZOLIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2010-04-08 | — | — | WO | claimed |
| WO-2010038200-A1 | OXAZOLIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2010-04-08 | — | — | WO | disclosed |