Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 12/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31503655 | 0.93 | ALDH1A1 (0.53) | ALDH1A1KDM4EUSP2POLBL3MBTL1 | |
| SCHEMBL1981958 | 0.87 | KDM4E (0.55) | ALDH1A1KDM4EUSP2POLBL3MBTL1 | |
| SCHEMBL1708651 | 0.85 | KDM4E (0.49) | ALDH1A1KDM4EUSP2POLBL3MBTL1 | |
| SCHEMBL1511834 | 0.84 | ALDH1A1 (0.60) | ALDH1A1KDM4EUSP2ARIMPDH2 | |
| SCHEMBL8777864 | 0.82 | ALDH1A1 (0.58) | ALDH1A1KDM4EUSP2POLBL3MBTL1 | |
| SCHEMBL10985027 | 0.81 | POLB (0.47) | ALDH1A1KDM4EPOLBL3MBTL1MAPT | |
| Hydrochloric Acid SCHEMBL11411334 | 0.81 | ALDH1A1 (0.56) | ALDH1A1KDM4EUSP2POLBL3MBTL1 | |
| SCHEMBL31554560 | 0.79 | ALDH1A1 (0.55) | ALDH1A1KDM4EUSP2POLBL3MBTL1 | |
| SCHEMBL24823994 | 0.78 | POLB (0.62) | ALDH1A1KDM4EUSP2POLBL3MBTL1 | |
| SCHEMBL14720180 | 0.78 | ALDH1A1 (0.44) | ALDH1A1KDM4EUSP2ARIMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393781-B1 | DIHYDROPYRIDONE UREAS AS P2X7 MODULATORS | HOFFMANN LA ROCHE (CH) | 2014-03-12 | — | — | EP | disclosed |
| EP-2393781-A1 | DIHYDROPYRIDONE UREAS AS P2X7 MODULATORS | F. Hoffmann-La Roche AG (CH) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010072599-A1 | DIHYDROPYRIDONE UREAS AS P2X7 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-07-01 | — | — | WO | disclosed |
| US-20100160388-A1 | DIHYDROPYRIDONE UREAS AS P2X7 MODULATORS | ROCHE PALO ALTO LLC | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160388-A1 | DIHYDROPYRIDONE UREAS AS P2X7 MODULATORS | P2RY1, P2RX1, P2RX3 | ALDH1A1 1399/4885KDM4E 2644/4885USP2 2698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.