Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 17/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | GPR6 | P46095 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3343321 | 0.91 | GPR119 (0.55) | GPR119KCNH2GPR6 | |
| SCHEMBL3343346 | 0.89 | GPR119 (0.52) | GPR119KCNH2GPR6 | |
| SCHEMBL3349535 | 0.85 | GPR119 (0.54) | GPR119KCNH2 | |
| SCHEMBL3344924 | 0.83 | GPR119 (0.45) | GPR119KCNH2 | |
| SCHEMBL3346504 | 0.82 | GPR119 (0.44) | GPR119GPR6 | |
| SCHEMBL3343283 | 0.81 | GPR119 (0.63) | GPR119 | |
| SCHEMBL13423111 | 0.78 | GPR119 (0.57) | GPR119KCNH2 | |
| SCHEMBL19434286 | 0.77 | GPR119 (0.50) | GPR119 | |
| SCHEMBL19450830 | 0.77 | GPR119 (0.52) | GPR119 | |
| SCHEMBL2555720 | 0.77 | GPR119 (0.58) | GPR119KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |