Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | VNN1 | O95497 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3347179 | 0.88 | POLB (0.39) | NAMPTAKR1C3MAPTALDH1A1KCNH2 | |
| SCHEMBL14626554 | 0.87 | MAPT (0.46) | MAPTALDH1A1HRH3POLBL3MBTL1 | |
| SCHEMBL7474533 | 0.86 | L3MBTL1 (0.56) | MAPTALDH1A1HRH3POLBL3MBTL1 | |
| SCHEMBL30206646 | 0.83 | MAPT (0.58) | MAPTALDH1A1HRH3KCNH2L3MBTL1 | |
| SCHEMBL13873084 | 0.83 | NAMPT (0.42) | NAMPTAKR1C3MAPTALDH1A1HRH3 | |
| Hydrochloric Acid SCHEMBL10806945 | 0.81 | MAPT (0.57) | MAPTALDH1A1HRH3KCNH2L3MBTL1 | |
| SCHEMBL13290439 | 0.81 | AKR1C3 (0.46) | NAMPTAKR1C3POLBL3MBTL1NPC1 | |
| SCHEMBL22968141 | 0.81 | AKR1C3 (0.46) | NAMPTAKR1C3POLBL3MBTL1NPC1 | |
| SCHEMBL19277071 | 0.81 | AKR1C3 (0.46) | NAMPTAKR1C3POLBL3MBTL1NPC1 | |
| SCHEMBL20590901 | 0.79 | AKR1C3 (0.47) | NAMPTAKR1C3POLBL3MBTL1VNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | claimed |
| EP-1250332-A1 | INHIBITORS OF INTERLEUKIN 5 GENE EXPRESSION | Abbott Laboratories (US) | 2002-10-23 | — | — | EP | claimed |
| WO-2001044223-A1 | INHIBITORS OF INTERLEUKIN 5 GENE EXPRESSION | ABBOTT LABORATORIES (US) | 2001-06-21 | — | — | WO | claimed |
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |