Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.59 |
| ▸ | MEN1 | O00255 | 8/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3339972 | 0.82 | MAPT (0.65) | KMT2AMEN1ADRB2ADRB1ADRB3 | |
| SCHEMBL3339934 | 0.76 | MEN1 (0.57) | KMT2AMEN1ADRB2ADRB1ADRB3 | |
| SCHEMBL1904253 | 0.76 | KMT2A (0.59) | KMT2AMEN1ADRB2ADRB1ADRB3 | |
| SCHEMBL1900504 | 0.75 | POLB (0.73) | KMT2AMEN1LMNAMAPTALDH1A1 | |
| SCHEMBL21485252 | 0.73 | MEN1 (0.73) | KMT2AMEN1LMNAMAPK1MAPT | |
| SCHEMBL1899118 | 0.72 | KMT2A (0.53) | KMT2AMEN1LMNAMAPK1MAPT | |
| SCHEMBL14938246 | 0.72 | DRD2 (0.54) | KMT2AMEN1ADRB2ADRB1ADRB3 | |
| SCHEMBL3340162 | 0.71 | HTT (0.72) | KMT2AMEN1AURKAADRB2ADRB1 | |
| SCHEMBL16689557 | 0.70 | RBP4 (0.62) | KMT2AMEN1LMNAMAPK1MAPT | |
| SCHEMBL3339777 | 0.70 | MAPT (0.49) | KMT2AMEN1ADRB2ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100063047-A1 | AMINOPYRIMIDINE INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063047-A1 | AMINOPYRIMIDINE INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | HRH4, HRH2, HRH3 | KMT2A 578/4885MEN1 2315/4885AURKA 1443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.