Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | RPA1 | P27694 | 1/20 | 0.56 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.55 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.55 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PRNP | P04156 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1772679 | 0.81 | ALDH1A1 (0.84) | ALDH1A1HPGDKDM4ERPA1NR4A1 | |
| SCHEMBL3346332 | 0.81 | MAPT (0.57) | ALDH1A1HPGDKDM4ERPA1NR4A1 | |
| SCHEMBL3418331 | 0.80 | ALDH1A1 (0.70) | ALDH1A1HPGDKDM4ERPA1NR4A1 | |
| SCHEMBL4532675 | 0.78 | NR4A1 (0.67) | ALDH1A1HPGDKDM4ERPA1NR4A1 | |
| SCHEMBL3000139 | 0.76 | KDM4E (0.57) | ALDH1A1HPGDKDM4ERPA1NR4A1 | |
| SCHEMBL3731167 | 0.76 | RPA1 (0.74) | ALDH1A1HPGDKDM4ERPA1NR4A1 | |
| SCHEMBL27952578 | 0.75 | ALDH1A1 (0.68) | ALDH1A1HPGDKDM4ERPA1NR4A1 | |
| SCHEMBL7236510 | 0.75 | ALDH1A1 (0.67) | ALDH1A1HPGDKDM4ERPA1NR4A1 | |
| SCHEMBL7138575 | 0.74 | ALDH1A1 (0.65) | ALDH1A1HPGDKDM4ENR4A1NR4A2 | |
| SCHEMBL307282 | 0.74 | ALDH1A1 (0.92) | ALDH1A1HPGDKDM4ENR4A1NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8338367-B2 | Fused heteroaryl diamide compounds useful as MMP-13 inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-12-25 | — | — | US | disclosed |
| WO-2010045190-A1 | FUSED HETEROARYL DIAMIDE COMPOUNDS USEFUL AS MMP-13 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-04-22 | — | — | WO | disclosed |