Sugi Predict

Sugi Predict / Compounds / SCHEMBL307282

SCHEMBL307282

SCHEMBL307282

O=C(O)c1ccc(-c2ccccc2)o1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 3/20 0.92
▸ HPGD P15428 2/20 0.92
▸ NR4A1 P22736 1/20 0.66
▸ NR4A2 P43354 1/20 0.66
▸ NR4A3 Q92570 1/20 0.66
▸ SLC9A1 P19634 1/20 0.61
▸ ERCC5 P28715 1/20 0.61
▸ FEN1 P39748 1/20 0.61
▸ MEN1 O00255 1/20 0.59
▸ KMT2A Q03164 1/20 0.59
▸ NPSR1 Q6W5P4 1/20 0.59
▸ KDM4E B2RXH2 1/20 0.56
▸ HSD17B10 Q99714 1/20 0.56
▸ TDP1 Q9NUW8 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1772679 0.91 ALDH1A1 (0.84) ALDH1A1HPGDNR4A1NR4A2NR4A3
SCHEMBL28758613 0.89 ALDH1A1 (0.81) ALDH1A1HPGDNR4A1NR4A2NR4A3
SCHEMBL9484980 0.87 ALDH1A1 (0.71) ALDH1A1HPGDNR4A1NR4A2NR4A3
SCHEMBL7138575 0.84 ALDH1A1 (0.65) ALDH1A1HPGDNR4A1NR4A2NR4A3
SCHEMBL221022 0.83 ALDH1A1 (0.67) ALDH1A1HPGDNR4A1NR4A2NR4A3
SCHEMBL4163540 0.83 ALDH1A1 (0.68) ALDH1A1HPGDNR4A1NR4A2NR4A3
SCHEMBL8805929 0.83 ALDH1A1 (0.67) ALDH1A1HPGDNR4A1NR4A2NR4A3
SCHEMBL15314439 0.83 ALDH1A1 (0.67) ALDH1A1HPGDNR4A1NR4A2NR4A3
SCHEMBL25275688 0.82 ALDH1A1 (0.71) ALDH1A1HPGDNR4A1NR4A2NR4A3
SCHEMBL242273 0.82 ALDH1A1 (0.70) ALDH1A1HPGDNR4A1NR4A2NR4A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 241 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7842696-B2 Piperazine derivatives as inhibitors of stearoyl-CoA desaturase FOREST LABORATORIES HOLDINGS LIMITED (BM) 2010-11-30 — — US claimed
US-7816371-B2 Bicycloheteroaryl compounds as P2X7 modulators and uses thereof RENOVIS, INC. (US) 2010-10-19 — — US claimed
US-20090221583-A1 NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE FOREST LABORATORIES HOLDINGS LIMITED (BM) 2009-09-03 — — US claimed
US-20080242671-A1 INHIBITORS OF CATHEPSIN S IRM LLC (BM) 2008-10-02 — — US claimed
US-20060052365-A1 Protease inhibitors SMITHKLINE BEECHAM CORPORATION 2006-03-09 — — US claimed
JP-2006505526-A — — 2006-02-16 — — JP claimed
EP-1539178-A2 PROTEASE INHIBITORS SmithKline Beecham Corporation (US) 2005-06-15 — — EP claimed
WO-2004017911-A2 PROTEASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2004-03-04 — — WO claimed
CN-119264155-A Latent curing agent based on dynamic crosslinking-controllable dissolution mechanism 江南大学 2025-01-07 — — CN disclosed
CN-118878479-A Derivative compound of 1,3,4 thiadiazole thioacetamide, and preparation method and application thereof 贵州大学 2024-11-01 — — CN disclosed
CN-118026956-A Derivative compound of 1,3,4 thiadiazole thioacetamide, and preparation method and application thereof 贵州大学 2024-05-14 — — CN disclosed
EP-3002280-B1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS UNIV GREENWICH (GB) 2023-05-24 — — EP disclosed
US-11001594-B2 Heterocyclic modulators of HIF activity for treatment of disease BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2021-05-11 — — US disclosed
US-11001594-B2 Heterocyclic modulators of HIF activity for treatment of disease BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2021-05-11 — — US disclosed
US-4643996-A 5-phenyl-2-furoic acid hydrazides NORWICH EATON PHARMACEUTICALS, INC. (US) 1987-02-17 — — US disclosed
US-4264325-A INCLUDING POLYACRYLONITRILE, POLYESTERS, CELLULOSE ACETATES, AND POLYAMIDES CIBA-GEIGY CORPORATION (US) 1981-04-28 — — US disclosed
US-4222946-A ANTIALLERGEN, HYPERSENSITIVITY LILLY INDUSTRIES, LIMITED (GB) 1980-09-16 — — US disclosed
US-4189589-A OPTICAL BRIGHTENERS FOR TEXTILES CIBA-GEIGY CORPORATION (US) 1980-02-19 — — US disclosed
US-4187232-A ANTIALLERGENS LILLY INDUSTRIES LIMITED (GB) 1980-02-05 — — US disclosed
US-4123529-A TREATMENT OF ASTHMA LILLY INDUSTRIES LIMITED (GB) 1978-10-31 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060052365-A1 Protease inhibitors CTSS, CTSE, CMA1 ALDH1A1 1528/4885HPGD 1420/4885NR4A1 3549/4885
US-20080242671-A1 INHIBITORS OF CATHEPSIN S CTSS, CTSB, CTSZ ALDH1A1 3512/4885HPGD 3267/4885NR4A1 4520/4885
US-11001594-B2 Heterocyclic modulators of HIF activity for treatment of disease HIF1AN, HIF1A, EGLN3 ALDH1A1 546/4885HPGD 22/4885NR4A1 1891/4885
US-20090221583-A1 NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE SCD, SCD5, FADS2 ALDH1A1 969/4885HPGD 503/4885NR4A1 3541/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.