Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGL | P35573 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MGAM | O43451 | 1/20 | 0.31 |
| ▸ | GBA1 | P04062 | 1/20 | 0.31 |
| ▸ | LCT | P09848 | 1/20 | 0.31 |
| ▸ | SI | P14410 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21901114 | 0.81 | AGL (0.35) | AGLGAATDP1MGAMGBA1 | |
| SCHEMBL13849313 | 0.79 | GBA1 (0.35) | GBA1 | |
| SCHEMBL22098703 | 0.79 | GBA1 (0.35) | GBA1 | |
| SCHEMBL10131847 | 0.79 | SIGMAR1 (0.36) | — | |
| SCHEMBL12942345 | 0.79 | SIGMAR1 (0.36) | — | |
| SCHEMBL12942344 | 0.79 | SIGMAR1 (0.36) | — | |
| SCHEMBL27027460 | 0.77 | DRD3 (0.31) | — | |
| SCHEMBL19958962 | 0.77 | DRD3 (0.31) | — | |
| SCHEMBL15416023 | 0.75 | MAPT (0.33) | — | |
| SCHEMBL3921405 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |