Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTSR1 | P30989 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LGMN | Q99538 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 4/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | INSR | P06213 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL310068 | 1.00 | NTSR1 (0.43) | NTSR1ALDH1A1CYP3A4TSHRHSD17B10 | |
| SCHEMBL30682434 | 1.00 | NTSR1 (0.43) | NTSR1ALDH1A1CYP3A4TSHRHSD17B10 | |
| SCHEMBL10205069 | 0.92 | ALK (0.43) | NTSR1ALDH1A1LGMNCHEK1SUV39H2 | |
| SCHEMBL5406594 | 0.91 | DPP4 (0.46) | NTSR1ALDH1A1CYP3A4TSHRHSD17B10 | |
| Hydrochloric Acid SCHEMBL5387731 | 0.90 | DPP4 (0.45) | NTSR1ALDH1A1CYP3A4SUV39H2DPP4 | |
| SCHEMBL24073829 | 0.88 | CHEK1 (0.46) | NTSR1ALDH1A1CYP3A4LGMNCHEK1 | |
| SCHEMBL17265199 | 0.88 | ALDH1A1 (0.46) | ALDH1A1CYP3A4TSHRHSD17B10TDP1 | |
| SCHEMBL520117 | 0.87 | SLC6A4 (0.40) | NTSR1LGMNSUV39H2DPP4PDE7A | |
| SCHEMBL519205 | 0.87 | SLC6A4 (0.40) | NTSR1LGMNSUV39H2DPP4PDE7A | |
| SCHEMBL519204 | 0.87 | SLC6A4 (0.40) | NTSR1LGMNSUV39H2DPP4PDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |