Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 4/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.39 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | QDPR | P09417 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19002794 | 0.81 | DRD3 (0.47) | DRD3 | |
| SCHEMBL4779850 | 0.80 | DRD3 (0.55) | DRD3 | |
| SCHEMBL13362111 | 0.80 | QDPR (0.55) | PDE4BQDPR | |
| SCHEMBL2957074 | 0.80 | DRD3 (0.49) | DRD3HTR4QDPR | |
| SCHEMBL19002671 | 0.80 | DRD3 (0.46) | DRD3HTT | |
| SCHEMBL28807580 | 0.76 | EPHX2 (0.43) | DRD3HTT | |
| SCHEMBL19002796 | 0.76 | EPHX2 (0.43) | DRD3 | |
| SCHEMBL19002793 | 0.76 | MEN1 (0.46) | DRD3 | |
| SCHEMBL14035660 | 0.76 | USP30 (0.51) | DRD3HTT | |
| SCHEMBL19002798 | 0.75 | DRD3 (0.65) | DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |