Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 10/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTR4 | Q13639 | 4/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | QDPR | P09417 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4779850 | 0.85 | DRD3 (0.55) | DRD3ALDH1A1CHEK1 | |
| SCHEMBL2952074 | 0.83 | MEN1 (0.42) | DRD3ALDH1A1ADRA2CADRA1B | |
| SCHEMBL3345717 | 0.81 | DRD3 (0.51) | DRD3HTR4CHEK1CHRM4CHRM5 | |
| SCHEMBL3345708 | 0.80 | DRD3 (0.44) | DRD3HTR4QDPR | |
| SCHEMBL520283 | 0.74 | PDE4B (0.51) | QDPR | |
| SCHEMBL28829545 | 0.74 | DRD3 (0.53) | DRD3 | |
| SCHEMBL28071280 | 0.74 | DRD3 (0.53) | DRD3HTR2B | |
| SCHEMBL28050491 | 0.74 | DRD3 (0.53) | DRD3 | |
| SCHEMBL28071470 | 0.74 | DRD3 (0.53) | DRD3HTR2B | |
| SCHEMBL28071433 | 0.74 | DRD3 (0.53) | DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111406-A2 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | disclosed |
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |