Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.35 |
| ▸ | CSF1R | P07333 | 3/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29692870 | 0.87 | EGFR (0.41) | KCNH2EGFR | |
| SCHEMBL592407 | 0.87 | EGFR (0.41) | KCNH2EGFR | |
| SCHEMBL2821252 | 0.82 | PDGFRB (0.36) | PDGFRBPDGFRACSF1RMAP4K4NPC1 | |
| SCHEMBL18544262 | 0.82 | PDGFRB (0.36) | KCNH2PDGFRBPDGFRACSF1RMAP4K4 | |
| SCHEMBL3346945 | 0.81 | ERN1 (0.44) | PDGFRBPDGFRACSF1RMAP4K4NPC1 | |
| SCHEMBL2821504 | 0.80 | KCNH2 (0.37) | KCNH2PDGFRBPDGFRACSF1R | |
| SCHEMBL22996915 | 0.78 | KCNH2 (0.37) | KCNH2PDGFRBPDGFRACSF1R | |
| SCHEMBL20687532 | 0.78 | PDGFRB (0.34) | KCNH2PDGFRBPDGFRACSF1RCYP11B2 | |
| SCHEMBL14993933 | 0.77 | CSF1R (0.33) | KCNH2PDGFRBPDGFRACSF1RMAP4K4 | |
| SCHEMBL18544261 | 0.77 | KCNH2 (0.37) | KCNH2PDGFRBPDGFRACSF1RMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010046388-A1 | SUBSTITUTED (AZA) -1-METHYL-1H-QUINOLIN-2-ONES AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010045987-A1 | SUBSTITUTED (AZA) -1-METHYL-1H-QUIN0LIN-2-0NES AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010046388-A1 | SUBSTITUTED (AZA) -1-METHYL-1H-QUINOLIN-2-ONES AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2010-04-29 | — | — | WO | disclosed |