Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.40 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.40 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2614354 | 0.77 | NPC1 (0.64) | NPC1KDM4EGAAHSD17B10L3MBTL1 | |
| SCHEMBL3345938 | 0.77 | KDM4E (0.44) | NPC1KDM4EGAAHSD17B10L3MBTL1 | |
| SCHEMBL3346696 | 0.73 | NPC1 (0.53) | NPC1KDM4EGAAHSD17B10L3MBTL1 | |
| SCHEMBL15908507 | 0.73 | NPC1 (0.67) | NPC1KDM4EGAAHSD17B10L3MBTL1 | |
| SCHEMBL27942525 | 0.72 | NPC1 (0.49) | NPC1KDM4EGAAHSD17B10L3MBTL1 | |
| SCHEMBL14456078 | 0.71 | HSP90AA1 (0.50) | NPC1KDM4EGAAHSD17B10L3MBTL1 | |
| SCHEMBL5271661 | 0.71 | NPC1 (0.60) | NPC1KDM4EGAAHSD17B10L3MBTL1 | |
| SCHEMBL2807338 | 0.71 | CYP3A4 (0.65) | NPC1KDM4EGAAHSD17B10PLA2G7 | |
| SCHEMBL10099699 | 0.70 | KDM4E (1.00) | NPC1KDM4EGAAHSD17B10L3MBTL1 | |
| SCHEMBL9901481 | 0.70 | CCR1 (0.48) | NPC1KDM4EHSD17B10PLA2G7SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | ROCHE PALO ALTO LLC | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | P2RY1, P2RX6, P2RX3 | NPC1 1906/4885KDM4E 2591/4885GAA 3977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.